Evidence map›Paper›PMID 40967637›Full record

ArticleCell proliferation2025

Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis.

Yaqian Li, Tian Li, Fuyu Jin, Shupeng Liu, Dingjie Xu, Zhongqiu Wei, Xuemin Gao, Wenchen Cai, Na Mao, Fang Yang and 3 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yaqian LiCollege of TCM, North China University of Science and Technology, Tangshan, China.
Tian LiCollege of Nursing, North China University of Science and Technology, Tangshan, China.ORCID https://orcid.org/0000-0002-3196-2750
Fuyu JinSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Shupeng LiuSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Dingjie XuCollege of TCM, North China University of Science and Technology, Tangshan, China.
Zhongqiu WeiBasic Medicine College, North China University of Science and Technology, Tangshan, China.ORCID https://orcid.org/0000-0002-1895-7295
Xuemin GaoSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Wenchen CaiSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Na MaoSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Fang YangSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Haibo ZhangDepartment of Anesthesiology and Pain Medicine, Department of Physiology, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Yiwei ShiNHC Key Laboratory of Pneumoconiosis, Shanxi Key Laboratory of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0009-0008-7926-0871
Hong XuHealth Science Center, Hebei Key Laboratory of Integrated Utilization of Saline Alkali Land in Medical Engineering, Key Laboratory for Quality of Salt Alkali Resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, China.ORCID https://orcid.org/0000-0002-3655-3833

Funding

National Natural Science Foundation of China 82473607Natural Science Foundation of Hebei Province H2023209084the Science and Technology Project of Hebei 23372505Dthe Science and Technology Project of Hebei 252W2502Dthe Science and Technology Project of Hebei Education Department QN2025407
6 · The paper itself

Abstract

Targeting macrophage SCTR mitigates integrated profibrotic, inflammatory, ER stress, and senescent pathways, preserving lung function and revealing a novel therapeutic strategy for silicosis.

Indexed as

MacrophagesPulmonary FibrosisReceptors, Gastrointestinal HormoneReceptors, G-Protein-CoupledSilicon DioxideAnimalsEndoplasmic Reticulum StressHumansMiceSilicosisReceptors, Gastrointestinal HormoneReceptors, G-Protein-CoupledSilicon Dioxide

Identifiers

PMID40967637
PMCPMC12686129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.