ArticleBMJ paediatrics open2025
Clinical characteristics and pharmacotherapy choices in children newly diagnosed with tic disorders in China: a retrospective cohort study.
Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- TIC-XNet: a structured evidence translation framework for interpretable multimodal pediatric tic event detection with improved temporal alignment and fidelity.Frontiers in psychiatry · 2026Article
- Towards precision medicine in Tourette syndrome: a perspective on AI-driven predictive modelling and personalised care.Frontiers in computational neuroscience · 2026Review
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5 authors.
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Abstract
objectiveThis study aims to characterise the clinical profiles and pharmacotherapeutic choices among children with newly diagnosed tic disorders (TDs) in China in order to improve clinical understanding and support decision-making for clinicians.
methodsThis was a retrospective cohort study involving 15 182 paediatric patients aged 4-18 years newly diagnosed with TD at Wuhan Children's Hospital between January 2021 and October 2024. Demographic characteristics and initial pharmacotherapy choices were collected and analysed. Clinical characteristics were compared across age (<6 years, 6-12 years and ≥12 years) and gender groups using χ
resultsAmong the patients, 78.6%, 9.9% and 11.5% were diagnosed with provisional TD, chronic TD (CTD) and Tourette syndrome (TS), respectively. The median age at diagnosis was 7.3 years, with a male-to-female ratio of 3.7:1. The most common symptom was eye blinking/eye rolling. The rate of premonitory urge and the tic-related impact tended to increase with age. Male patients showed a higher prevalence of CTD and TS, as well as a greater comorbidity rate of attention-deficit/hyperactivity disorder. And the rate of male patients was slightly positively correlated with age at onset. Most patients chose the monotherapy for the first time. Among them, the clonidine patch and traditional Chinese medicine were the most common choices.
conclusionsWe described the clinical phenotypes of paediatric patients with newly diagnosed TD in China. At the same time, we also explored the differences in TD subtypes, clinical characteristics and medication choices between patients in different age and gender groups, providing valuable real-world evidence for an early identification and individualised treatment in paediatric TD.
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