ArticleNeuron2025
Variation in moment-to-moment brain state engagement follows a consistent trajectory during development.
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Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed.
- External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging.Nature methods · 2026Review
- Flexible brain state engagement predicts cognitive control transdiagnostically.bioRxiv : the preprint server for biology · 2026Article
- Atypical Development of Functional Brain Networks in Neonates with Congenital Heart Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
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Authors and funding
38 authors.
Jean YeInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA. Electronic address: jean.ye@yale.edu.
Link TejavibulyaInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA.
Wei DaiDepartment of Biostatistics, Yale School of Public Health, New Haven, CT 06511, USA.
Lora M CopeDepartment of Psychiatry and Addiction Center, University of Michigan, Ann Arbor, MI 48109, USA.
Jillian E HardeeDepartment of Psychiatry and Addiction Center, University of Michigan, Ann Arbor, MI 48109, USA.
Mary M HeitzegDepartment of Psychiatry and Addiction Center, University of Michigan, Ann Arbor, MI 48109, USA.
Sarah LichensteinDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
Sarah W YipDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA; Child Study Center, Yale School of Medicine, New Haven, CT 06511, USA.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Gareth J BakerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine, and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany; Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany.
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany.
Penny GowlandSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; German Center for Mental Health (DZPG), Berlin, Germany; German Center for Mental Health (DZPG), Potsdam, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France; AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France; Psychiatry Department, EPS Barthélémy Durand, Etampes, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
Dimitri Papadopoulos OrfanosDepartment of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany.
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Christian BaeuchlDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannGerman Center for Mental Health (DZPG), Berlin, Germany; German Center for Mental Health (DZPG), Potsdam, Germany; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington, VT 05405, USA; Department of Psychology, University of Vermont, Burlington, VT 05405, USA.
Bader ChaaraniDepartment of Psychiatry, University of Vermont, Burlington, VT 05405, USA.
Dylan G GeeDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA; Child Study Center, Yale School of Medicine, New Haven, CT 06511, USA; Department of Psychology, Yale University, New Haven, CT 06511, USA.
Arielle Baskin-SommersDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA; Department of Psychology, Yale University, New Haven, CT 06511, USA.
B J CaseyDepartment of Neuroscience and Behavior, Barnard College, Columbia University, New York, NY 10027, USA.
IMAGEN Consortium
Dustin ScheinostInterdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA; Child Study Center, Yale School of Medicine, New Haven, CT 06511, USA; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06511, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA; Department of Statistics & Data Science, Yale University, New Haven, CT 06511, USA; Yale Biomedical Imaging Institute, Yale School of Medicine, New Haven, CT 06511, USA.
Funding
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MHuman Translational Applications Core (HTA - Core) (7 of 8)PL1MH083271 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2011
$5.8MTranslational Methods/Facilities Core (TMF - Core) (8 of 8)PL1NS062410 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EVANS, CHRISTOPHER J. · 2007 to 2011
$4.6MA decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9MTranslational Models of Memory and Cognitive Control (Component 5 of 8)RL1MH083270 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENTSCH, J. DAVID · 2007 to 2011
$2.6MWhole Genome Assoc. Analysis Strategies for Multi. PhenotypesRL1MH083268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$2.1MConsortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9MMemory Mechanisms and Mental DisordersRL1MH083269 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2007 to 2011
$1.8MResponse Inhibition and Dopamine Neurotransmission (RI) (4 of 8)RL1DA024853 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2007 to 2011
$1.7MHypothesis Web Development for Neuropsychiatric Phenomics (6 of 8)RL1LM009833 · NLM · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PARKER, DOUGLASS STOTT · 2007 to 2011
$1.5MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kNIAAA NIH HHS F31 AA032179NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIDA NIH HHS RL1 DA024853NIDCR NIH HHS UL1 DE019580NIMH NIH HHS PL1 MH083271NIMH NIH HHS RL1 MH083268NIMH NIH HHS RL1 MH083269NIMH NIH HHS RL1 MH083270NIMH NIH HHS U54 MH091657NINDS NIH HHS PL1 NS062410NLM NIH HHS RL1 LM009833
Abstract
Neural variability, or variation in brain signals, facilitates dynamic brain responses to ongoing demands. This flexibility is important during development from childhood to young adulthood, a period characterized by rapid changes in experience. However, little is known about how variability in moment-to-moment brain state engagement changes during development. Such investigations would require the continuous assessment of multiple brain states concurrently. Here, we leverage a new computational framework to characterize the state engagement variability (SEV) developmental trajectory. A consistent pattern of SEV changing with age is identified across cross-sectional and longitudinal datasets (N > 3,000). The SEV developmental trajectory stabilizes around mid-adolescence, with timing varying by sex and brain state. SEV successfully predicts executive function (EF) in youth from an independent dataset. Deviations in SEV development are further linked to worse EF. These converging findings suggest that SEV changes over development, allowing individuals to flexibly recruit various brain states to meet evolving needs.
Indexed as
BrainExecutive FunctionAdolescentAdultChildCross-Sectional StudiesFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleYoung Adultbrain dynamicsdevelopmentexecutive functionfMRIneural variability
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