ArticleCell2025
Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn's disease strictures.
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
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Who cites it
24 citing papers in PubMed.
- Review
- Dual-energy computed tomography quantification of creeping fat in Crohn's disease: A new radiologic biomarker for transmural disease monitoring.World journal of radiology · 2026Article
- Crohn's Disease: From Immune Dysregulation to Intestinal Damage.Inflammation · 2026Review
- Intestinal muscularis in health and disease.Communications biology · 2026Review
- Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.JCI insight · 2026Review
- IL11+ fibroblasts are implicated in nonresponse to anti-TNF-α via fibrosis in inflammatory bowel disease.JCI insight · 2026Article
- Value of dual energy computed tomography with material decomposition algorithm in assessing intestinal creeping fat in Crohn's disease.World journal of radiology · 2026Article
- Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation.Science (New York, N.Y.) · 2026Article
- PDGF signaling regulates the adipocyte-to-fibroblast transition in wound healing.Cell reports · 2026Article
- Protocol to interrogate the role of creeping fat and mechanical tension in Crohn's disease using a surgical mouse model of intestinal fibrosis.STAR protocols · 2026Article
- Wnt/β-catenin signaling regulates fibrotic atrophy of intra-articular adipose tissue in post-traumatic osteoarthritis.bioRxiv : the preprint server for biology · 2026Article
- Targeting fibroblasts in immune mediated inflammatory diseases: a cellular basis for cure?Rheumatology (Oxford, England) · 2026Review
- Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease.European journal of immunology · 2026Review
- Tissue-layer-resolved proteome landscape of Crohn's disease strictures highlights potential drivers of fibrosis progression.JCI insight · 2026Article
- Inflammatory bowel disease and extracellular matrix: when victim becomes double agent.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Article
- Mechanosensitive ion channels in intestinal homeostasis and disease.eGastroenterology · 2026Review
- The role of lipid metabolism and creeping fat in disease assessment and prediction for Crohn's disease.Frontiers in immunology · 2026Review
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
- Cellular senescence in Crohn's disease: a double-edged sword in intestinal fibrosis.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
23 authors.
Khristian E Bauer-RoweHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Benjamin PhamHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michelle GriffinHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Norah E LiangHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexia KimHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
John M LuHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael JanuszykHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jason L GuoHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stefania De SantisDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Yue XingDepartment of Immunology and Immunotherapy, Department of Dermatology, Icahn School of Medicine, Mt. Sinai, New York, NY, USA.
Aleksandr PrystupaDepartment of Immunology and Immunotherapy, Department of Dermatology, Icahn School of Medicine, Mt. Sinai, New York, NY, USA.
Ikjot SidhuDepartment of Immunology and Immunotherapy, Department of Dermatology, Icahn School of Medicine, Mt. Sinai, New York, NY, USA.
Elijah J SuhHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Deshka S FosterHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maria KorahHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alka GoyalDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Derrick C WanHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jeffrey A NortonHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Daniel DelittoHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Theresa T PizarroDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Shruti L NaikDepartment of Immunology and Immunotherapy, Department of Dermatology, Icahn School of Medicine, Mt. Sinai, New York, NY, USA.
Jeong S HyunHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: jhyun1@stanford.edu.
Michael T LongakerHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: longaker@stanford.edu.
Funding
Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE029463 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG, LOTZ, JEFFREY C. · 2020 to 2024
$29.5MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Fabio Cominelli · 2015 to 2026
$15.6MMedical Scientist Training ProgramT32GM145402 · NIGMS · STANFORD UNIVERSITY · PI Katrin F. Chua · 2022 to 2026
$10.0MThe pathogenic roles of GSDMD-dependent gut epithelium extracellular vesicles in IBDR01DK125293 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Theresa Torres Pizarro · 2021 to 2026
$3.3MMechanisms of immune-epithelial crosstalk in tissue repairR01AI168462 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Shruti Naik · 2022 to 2026
$3.1MOsteogenic Enrichment of Adipose Derived Stromal CellsR01DE021683 · NIDCR · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2012 to 2016
$2.0MDecoding mechanisms of early life inflammationR01AI184905 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Shruti Naik · 2025 to 2026
$1.6MReprogramming fibroblasts embryonic origins to overcome skin fibrosis and scarring.R01DE032677 · NIDCR · STANFORD UNIVERSITY · PI MICHAEL T LONGAKER, Derrick Wan · 2023 to 2026
$1.4MDefining the role of mechanoresponsive adipocyte-to-fibroblast transition in wound fibrosis.R01AR081343 · NIAMS · STANFORD UNIVERSITY · PI MICHAEL T LONGAKER, Derrick Wan · 2023 to 2026
$1.3MMechanoresponsive Engrailed-1-negative fibroblasts activate Engrailed-1 to promote fibrosis in wound healingR01GM136659 · NIGMS · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2020 to 2023
$1.3MAcquisition of a Leica TCS SP5 Confocal Microscope For A Multi-User FacilityS10OD016164 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CONRAD, PATRICIA A · 2013 to 2013
$597kCANCER ASSOCIATED FIBROBLAST CLONALITY, CHROMATIN ACCESSIBILITY AND THERAPEUTIC TARGETING IN PANCREATIC DUCTAL ADENOCARCINOMA STROMAF32CA239312 · NCI · STANFORD UNIVERSITY · PI FOSTER, DESHKA STONOROV · 2020 to 2020
$53kNCI NIH HHS F32 CA239312NIAID NIH HHS R01 AI168462NIAID NIH HHS R01 AI184905NIAMS NIH HHS R01 AR081343NIDCR NIH HHS R01 DE021683NIDCR NIH HHS R01 DE032677NIDCR NIH HHS U24 DE029463NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK125293NIGMS NIH HHS R01 GM136659NIGMS NIH HHS T32 GM145402NIH HHS S10 OD016164
Abstract
A significant complication of Crohn's disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the wrapping of mesenteric adipose tissue around diseased bowel, of which the role in CD stricture progression is unclear. By constructing a human single-cell CD fibroblast atlas, we identified CF-derived, CTHRC1+ fibroblasts enriched for Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signatures and localized to a fibrotic CF-bowel wall interface within the stricture. We further showed that analogous Cthrc1+ mouse fibroblasts derive from mesenteric adipose tissue stromal cells, infiltrate fibrotic bowel, and deposit extracellular matrix in a YAP/TAZ-dependent manner in a mouse model of intestinal fibrosis. Our findings identify CF as a key source of pro-fibrotic fibroblasts and raise the possibility of improving future clinical management of stricture progression by targeting not only the bowel but also CF.
Indexed as
Adipose TissueCrohn DiseaseIntestinesAnimalsDisease Models, AnimalExtracellular Matrix ProteinsFemaleFibroblastsGene Regulatory NetworksHumansMaleMiceMice, Inbred C57BLSignal TransductionTranscription, GeneticCTHRC1 protein, humanCthrc1 protein, mouseExtracellular Matrix Proteinscreeping fatCrohn’s diseasefibroblastsfibrosisinflammatory bowel diseasemeta-analysisscRNA-seqstricturesYes-associated protein
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