Evidence map›Paper›PMID 40966672›Full record

Trial reportThe British journal of surgery2025

A comparison of women and men with small abdominal aortic aneurysms.

Heather Ngai, Sydney Olson, John Curci, Andris Kazmers, Murray Shames, Shirling Tsai, William Blackwelder, Jon S Matsumura, Bernard Timothy Baxter, Michael Terrin and 1 more

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01756833 (Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01756833 phase2completednot on this map

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT)

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2013 to 2019Enrolled261ConditionsAneurysmArmsDoxycycline, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heather NgaiDepartment of Emergency Medicine, Harbor-University of California Los Angeles, Los Angeles, California, USA.
Sydney OlsonDepartment of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA.
John CurciDepartment of Vascular Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Andris KazmersDepartment of Surgery, McLaren Northern Michigan Hospital, Petoskey, Michigan, USA.
Murray ShamesDepartment of Vascular Surgery, University of South Florida, Tampa, Florida, USA.
Shirling TsaiDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
William BlackwelderDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jon S MatsumuraDepartment of Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Bernard Timothy BaxterDepartment of Surgery, University of Nebraska School of Medicine, Omaha, Nebraska, USA.
Michael TerrinDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jennifer S AlbrechtDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4838-2274

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT )R01AG037120 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI BAXTER, BERNARD TIMOTHY, CURCI, JOHN A · 2011 to 2017
$12.2M
Summer Program in Obesity, Diabetes and Nutrition Training (SPORT)T35DK095737 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI STEINLE, NANETTE I · 2012 to 2021
$859k
Doxycycline Treatment of Abdominal Aortic Aneurysm: PlanningR34AG028684 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L. · 2007 to 2007
$101k
NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG037120NIA NIH HHS R34 AG028684NIDDK NIH HHS T35 DK095737NIDDK NIH HHS T35DK095737Office of Women's HealthUniversity of MarylandUS National Institutes of Health
6 · The paper itself

Abstract

backgroundSex-related differences between men and women with small abdominal aortic aneurysms (AAAs) have implications for patient care and research. Women are less likely to be affected by AAA than men in the United States. This study explored sex-related differences in patient characteristics, aneurysm growth and clinical outcomes in the Non-invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT).

method: We conducted a retrospective cohort study performing a secondary analysis of data from N-TA3CT (NCT01756833), a placebo-controlled, RCT assessing doxycycline treatment of AAA. We included 166 N-TA3CT participants with baseline AAA maximum transverse diameter ≤ 4.5 cm and at least one follow-up CT scan. We compared patient characteristics, aneurysm growth rates, adverse events, and clinical outcomes between men and women.

resultsAmong 166 participants, 35 (21.1%) were women and 131 (78.9%) were men. Women were more likely than men to have a family history of AAA (31.4%% versus 16.0%, P = 0.05). Women were less likely to take statins (68.6% versus 84.7%, P = 0.05) or any antiplatelet agent (48.6% versus 77.9%, P = 0.001). Women had significantly faster annual AAA growth rates than men (0.21 versus 0.16 cm/year, P < 0.001).

conclusionsWithin the size range of 3.5-4.5 cm, AAAs grow faster in women than in men. Women with AAA report a family history of AAA more frequently than men do.

Indexed as

Aortic Aneurysm, AbdominalAgedDoxycyclineFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedRetrospective StudiesSex FactorsDoxycyclineHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID40966672
PMCPMC12445839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.