Evidence map›Paper›PMID 40966640›Full record

Observational studyOral diseases2026

Patient-Reported Oral Symptoms and Their Impact on Well-Being After Haematopoietic Cell Transplantation.

Kristina Skallsjö, Michael T Brennan, Bengt Hasséus, Jenny Öhman, Judith E Raber-Durlacher, Marie-Charlotte D N J M Huysmans, Alexa M G A Laheij, Stephanie J M van Leeuwen, Allan J Hovan, Karin Garming Legert and 5 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristina SkallsjöDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-7377-4208
Michael T BrennanDepartment of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.ORCID https://orcid.org/0000-0003-0638-4335
Bengt HasséusDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-3088-1550
Jenny ÖhmanDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-1162-7656
Judith E Raber-DurlacherDepartment of Oral Medicine, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0003-1500-8390
Marie-Charlotte D N J M HuysmansDepartment of Dentistry, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID https://orcid.org/0000-0002-3036-7554
Alexa M G A LaheijDepartment of Oral Medicine, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0003-1291-2798
Stephanie J M van LeeuwenDepartment of Dentistry, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID https://orcid.org/0000-0002-4522-3705
Allan J HovanOral Oncology and Dentistry, British Columbia Cancer, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0003-1639-5281
Karin Garming LegertDepartment of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.ORCID https://orcid.org/0000-0001-8276-0510
Scott IsomDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-6658-3865
David M KlineDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0001-6183-3303
Nicole M A BlijlevensDepartment of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID https://orcid.org/0000-0002-1801-2072
Jan-Erik JohanssonDepartment of Hematology and Coagulation, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-2674-9955
Inger von BültzingslöwenDepartment of Oral Microbiology and Immunology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-5509-4954

Funding

Stiftelsen Assar Gabrielssons Fond FB20-23Stiftelsen Assar Gabrielssons Fond FB21-55Svenska Tandläkare-Sällskapet 1468
6 · The paper itself

Abstract

objectiveOral complications may negatively influence outcomes of haematopoietic cell transplantation (HCT). A comprehensive view of oral symptoms and symptom burden post-HCT is lacking. This study aimed to determine the prevalence, severity, and temporal relationships of oral symptoms and their impact on well-being in the early post-HCT phase. Effects of transplant type and conditioning intensity were evaluated.

methodsIn this prospective multicentre observational study, adult HCT recipients were interviewed and completed questionnaires on oral symptoms and well-being three times a week during hospitalisation early post-HCT.

resultsOf 194 patients, 177 (91.2%) reported oral symptoms. Dry mouth was the earliest and most common (80.9%) followed by oral pain (35.6%), thickening/swollen mucosa (33.0%), and taste changes (30.9%). Symptom frequency peaked on days 6 to 11 post-HCT and caused significant burden: 59.3% experienced moderate to severe distress and 53.6% reported moderate to severe impact on well-being. Symptom prevalence was highest among patients who received allogeneic HCT with MAC and those who underwent autologous HCT. Overall, MAC regimens were associated with earlier and more frequent symptoms, greater distress and higher impact on well-being during days 0 to 11 post-HCT compared to reduced/non-myeloablative regimens.

conclusionsOral symptoms are prevalent, burdensome and significantly impact well-being early post-HCT, underscoring the need for close monitoring and supportive oral care.

Indexed as

Hematopoietic Stem Cell TransplantationMouth DiseasesAdultAgedFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPrevalenceProspective StudiesQuality of LifeTransplantation ConditioningXerostomiaYoung Adultadverse effectshaematopoietic cell transplantationmouth symptomsoral complicationspatient‐reported outcomesquality of life

Identifiers

PMID40966640
PMCPMC13077019

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.