Evidence map›Paper›PMID 40966590›Full record

ArticleJournal of animal science2025

Host genetics predominates over gut microbiota in serum copper levels in boars.

Liangliang Guo, Yueyue Miao, Jiajian Tan, Haiqing Sun, Siwen Jiang, Hongkui Wei, Jian Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liangliang GuoDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.ORCID 0009-0008-5164-6334
Yueyue MiaoDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Jiajian TanYangXiang Joint Stock Company, Guigang, China.
Haiqing SunYangXiang Joint Stock Company, Guigang, China.
Siwen JiangKey Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, China.
Hongkui WeiDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-7386-9936
Jian PengDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential trace element in numerous biological processes; maintaining its homeostasis is crucial for pig health and productivity. In this study, we employed a mixed-effects model to investigate the contributions of host genetics, gut microbiota, and their interactions with serum copper levels in pigs. We further explored potential candidate genes and microbiota associated with copper metabolism. The results demonstrated that host genetics exert a dominant influence on serum copper regulation compared to the effects of the gut microbiota. Furthermore, genome-wide association analysis identified 4 candidate genes, CPHL1, CP, NCEH1, and PDE10A, strongly linked to copper metabolism. By applying multiple association approaches, 10 bacterial genera, such as Blautia, Lachnospiraceae UCG-008, and Ruminococcaceae UCG-007 were found to be significantly correlated with serum copper levels. This research offers novel insights into the genetic and microbial determinants of copper variation in pigs, establishing a foundation for future genetic and microbiota-based strategies aimed at enhancing copper homeostasis and overall livestock health.

Indexed as

CopperGastrointestinal MicrobiomeSus scrofaAnimalsGenome-Wide Association StudyMaleSwineCopperBoarGenome-wide association studyGut microbiotaHost geneticsSerum copper level

Identifiers

PMID40966590
PMCPMC12448687

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.