ArticleNucleic acids research2025
The nuclear pore complex acts as a hub for pri-miRNA transcription and processing in plants.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- HASTY-dependent miRNA cell-to-cell movement is required for systemic pathogen resistance in Arabidopsis.Plant communications · 2026Article
- Trans-species microRNAs from the parasitic plant Cuscuta campestris specifically avoid loading onto self Argonautes.Nucleic acids research · 2026Article
- Should they stay or should they go? Regulating microRNA turnover in plants.The Plant cell · 2026Article
- Cross-kingdom RNAi: a universal mechanism of inter-organismal communication with many unknowns.Journal of experimental botany · 2026Review
- The nuclear cap-binding complex regulates subcellular RNA processing and surveillance of coding and noncoding RNAs.Nucleic acids research · 2026Article
- miRNA accumulation correlates with increased phloem cell proliferation in tomatoFrontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The regulation of miRNA biogenesis and movement is essential for plant development and environmental responses. HASTY (HST), a karyopherin protein, has been implicated in miRNA biogenesis and movement, though its role in non-cell-autonomous miRNA movement remains unclear. Through a genetic screen, we identified that mutations in the HAWAIIAN SKIRT (HWS) gene suppress the developmental defects of hst mutants by restoring miRNA movement. Our findings show that HWS interacts with nuclear transport factors and nuclear pore complex (NPC) components, including NUP1, positioning HWS as a regulator of miRNA nuclear export. Using microscopy and fluorescence in situ hybridization, we showed that pri-miRNA transcription, and likely their co-transcriptional processing, occur at the nuclear pore. Notably, we uncovered an antagonistic relationship between HST and HWS in regulating MIRNA transcription at the NPC and AGO1 loading, which could explain the observed changes in miRNA movement. HST promotes the association of MIRNA loci with the NPC, spatially positioning co-transcriptional processing by the NPC. Conversely, HWS negatively regulates this process by degrading MEDIATOR 37 subunits and detaching the processing complex from the NPC. Our data provide evidence of spatial coordination of miRNA transcription, biogenesis, and movement, highlighting a novel role for the NPC in the miRNA pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.