ArticleNucleic acids research2025
Integrating recombinase-based feedback and feedforward control for optimal resource decoupling.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Resource Competition and Growth Dilution Modulate Synthetic Gene Cascade Dynamics.ACS synthetic biology · 2026Article
- Harnessing CRISPRi Competition to Develop Multimodule Controllers for Resource-Aware Circuit Design.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Article
- CRISPRi-Linked Multimodule Negative Feedback Loops to Address Winner-Take-All Resource Competition.ACS synthetic biology · 2025Article
- CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition.bioRxiv : the preprint server for biology · 2025Article
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Abstract
Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromising genetic circuit function. While various control strategies have been explored, their complexity or limited efficacy have hindered broader application. Here, we present the Re-NF-FF-Controller, a recombinase-based strategy that integrates negative feedback and feedforward regulation via promoter flipping to mitigate resource competition. Computational modeling and experimental validation demonstrate that Re-NF-FF-Controller effectively reduces resource coupling, ensuring robust gene expression and modularity. Moreover, its tunability allows for performance optimization through straightforward adjustments of recombinase enzyme levels. This strategy offers a versatile and easily implementable solution for designing reliable synthetic biological systems.
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