ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Harnessing synthetic microbial communities for desert vegetation restoration.Synthetic and systems biotechnology · 2027Review
- Toward engineered microbial chassis for growth-production balancing.Synthetic and systems biotechnology · 2027Review
- Engineering of multiple modules to enhance lignocellulose degradation ability inSynthetic and systems biotechnology · 2026Article
- Trans-dimensional Bayesian model averaging for 13C-metabolic flux analysis: evidence-based flux inference under structural model uncertainty.Bioinformatics (Oxford, England) · 2026Article
- Biosynthesis and Microbial Production of Carminic Acid: From Pathway Elucidation to Synthetic Biology.Microorganisms · 2026Review
- Current Regulatory Frameworks for Bioactive Inputs in Plant Systems Producing Pharmaceutically Important Compounds.Plants (Basel, Switzerland) · 2026Review
- Engineering theACS synthetic biology · 2026Article
- EngineeringMicroorganisms · 2026Article
- High-Level Production of NMN inMicroorganisms · 2026Article
- Advances in microbial mevalonolactone production: from fermentative mevalonate accumulation to downstream lactonization.Engineering microbiology · 2026Review
- Metabolic Engineering of Yeasts: A Key Cell Factory Platform for Advanced Biomanufacturing.Journal of fungi (Basel, Switzerland) · 2025Article
- Optimization Strategy of Expression Vectors and Regulatory Elements for Enhanced Protein Production inInternational journal of molecular sciences · 2025Review
- Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The sustainable, bio-based production of industrially valuable chemicals and materials from renewable, non-edible biomass through biorefineries has emerged as a vital strategy for tackling urgent global challenges, including climate change, and for realizing the "net zero carbon" commitments recently pledged by nations worldwide. Metabolic engineering has played a central role in enabling the development of microbial strains capable of efficiently overproducing a diverse array of target compounds. Nevertheless, engineered microbial cell factories often face inherent trade-offs between product synthesis and cell growth, frequently resulting in diminished fitness or loss-of-function phenotypes. This review highlights recent advances in metabolic engineering strategies aims at reconciling this conflict, encompassing pathway optimization, dynamic regulation, orthogonal system design, microbial consortia engineering, fermentation process control, and integrative metabolic modeling. It also explores the remaining challenges and future directions for reprogramming microbial metabolism to harmonize growth with high-level production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.