ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- SPP1Journal for immunotherapy of cancer · 2026Article
- Regulatory networks of non-coding RNAs in renal cell carcinogenesis and therapeutic intervention strategies.World journal of urology · 2026Review
- Single-cell transcriptomic analysis reveals that the circRNA circGCLM promotes tumorigenesis and confers cisplatin resistance in NSCLC through the miR-505-3p/ERBB4 axis.Translational oncology · 2026Article
- Unveiling the epigenetic landscape: transforming renal cell carcinoma treatment.Clinical epigenetics · 2026Review
- Multi-omics analyses related to unfolded protein response in prostate cancer implicate pro-tumor role of IFRD1.Frontiers in immunology · 2026Article
- circPVT1 regulates EMT and induces macrophage polarization to promotes the progression of renal cell carcinoma.Frontiers in immunology · 2026Article
- CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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11 authors.
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Abstract
Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC). CircRNAs regulate gene expression via RNA-binding proteins (RBPs) and also exert biological effects through peptide encoding. CircPVT1 has been previously identified as an oncogenic circRNA. This study identified that circPVT1 encodes a 104-amino acid peptide, termed cP104aa. Functional assays showed that circPVT1 and the cP104aa peptide enhance RCC cell proliferation, invasion, migration, and lung metastasis both in vitro and in vivo. Mechanistically, the cP104aa peptide interacts with HNRNPK, leading to reduced c-MYC ubiquitination and increased c-MYC expression. Additionally, circPVT1 directly associates with EIF4A3, facilitating the expression of the target gene c-MYC. Furthermore, axitinib is shown to target the degradation of the cP104aa peptide. These findings reveal a novel mechanism by which circPVT1 contributes to RCC, highlighting the potential of the cP104aa peptide as a therapeutic target. Axitinib may serve as an effective therapeutic agent for patients with advanced RCC exhibiting high cP104aa expression.
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Registered trials
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