Evidence map›Paper›PMID 40966345›Full record

ArticleScience (New York, N.Y.)2025

Stereo-reversed E2 unlocks

Peter J Verardi, Elizabeth A Ryutov, Poulami Mukherjee, Remy Lalisse, Karina Targos, Tetsuya Inagaki, Megan Kelly, Ilia A Guzei, Marcel Schreier, Osvaldo Gutierrez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Photo-Stitching of Nitroalkanes via Cross-Denitrative Olefination.Journal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. Synthesis of 1,3-Dienes from Alkenes via Alkenyl Thianthrenium Salts.Journal of the American Chemical Society · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peter J VerardiDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.ORCID 0000-0002-5762-0708
Elizabeth A RyutovDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.ORCID 0009-0006-8021-4579
Poulami MukherjeeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2876-7612
Remy LalisseDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4556-5641
Karina TargosDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.ORCID 0000-0002-9945-0719
Tetsuya InagakiDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.
Megan KellyDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Engineering Hall, 1415 Engineering Drive, Madison, WI, USA.ORCID 0009-0003-5160-1041
Ilia A GuzeiDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.ORCID 0000-0003-1976-7386
Marcel SchreierDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Engineering Hall, 1415 Engineering Drive, Madison, WI, USA.ORCID 0000-0002-3674-5667
Osvaldo GutierrezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-8151-7519
Zachary K WickensDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.ORCID 0000-0002-5733-5288

Funding

New Directions in Sustainable Open-Shell Radical C-C Bond Formations Enabled by Merging Modern Computational and Experimental MethodsR35GM137797 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Osvaldo Gutierrez · 2020 to 2026
$2.7M
electrochemical dication pool: a new strategy to couple alkenes and abundant nucleophilesR01GM149674 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Zachary Kimble Wickens · 2023 to 2026
$1.2M
Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NIGMS NIH HHS R01 GM149674NIGMS NIH HHS R35 GM137797NIH HHS S10 OD012245NIH HHS S10 OD020022
6 · The paper itself

Abstract

The stereoselective functionalization of C-H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C-H activation chemistry, methods for

Identifiers

PMID40966345
PMCPMC12927436

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.