ArticlePloS one2025
Reward network mechanism in anhedonia and depression.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Abnormal resting-state functional connectivity in anhedonia: A systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). However, it is unclear whether anhedonia symptom and depressive episode share similar resting-state RN mechanism, as well as whether the RN mechanism is a state or trait-like marker of depression. This study aims to clarify the two points by recruitingboth current and remitted depression.
methodsUsing functional Magnetic Resonance Imaging (fMRI) scans, this study observed the resting-state RN function connectivity (with the seed of ventral striatum) in patients with remitted depression (RMD, n = 27) and current depression (n = 30) and 33 normal controls. The low-frequency fluctuation (ALFF) and T1 image were further analyzed.
resultsThree groups differed in anhedonia scores, with highest anhedonia in the MDD group and lowest anhedonia in the NC group. In total sample, higher anhedonia was correlated with weaker connectivity between the striatum seed and the putamen, inferior frontal cortex, insula, AC, and thalamus, while in the RMD group, anhedonia correlated with higher AC, thalamus, and caudate connectivity. In resting-state function connectivity, the MDD group possessed weaker connectivity between the striatum seed and inferior frontal cortex and insula, while the RMD group showed weaker connectivity with the caudate, and both the MDD and RMD groups possessed lower connectivity with the AC. ALFF data indicated a higher anterior cingulate (AC) activation in the MDD group than the RMD group.T1 image indicated a bigger thalamus volume in the MDD group than the RMD group.
conclusionsThe current study is among the first to confirm that RMD patients possess different RN pattern compared with MDD. Importantly, caudate playsa unique role in depression remission, AC and thalamus mechanisms are trait-like markers of depression. Surprisingly, insula and inferior frontal mechanisms share by depressive episode and anhedonia, while putamen discriminates depressive episode and anhedonia. The results suggest candidate biomarkers for the treatment of clinical depression.
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