Evidence map›Paper›PMID 40966282›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models.

Bhuvaneshwaran Subramanian, Shedreanna Johnson, Akshaya Narayanan, Wei Wang, Bonnie L Seaberg, Jillian Ball, Ilse M Paredes Mares, Ahana Majumder, Alexandria Aceves, Sarah E Frazier and 9 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Bhuvaneshwaran Subramanian *Department of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.
Shedreanna Johnson *Department of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0000-0002-2151-425X
Akshaya Narayanan *Department of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0000-0003-3285-736X
Wei WangDepartment of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0009-0009-7293-1115
Bonnie L SeabergDepartment of Neuroscience and Experimental Therapeutics, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0009-0002-2111-0164
Jillian BallDepartment of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.
Ilse M Paredes MaresDepartment of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0009-0000-5830-294X
Ahana MajumderDepartment of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0009-0002-6903-2716
Alexandria AcevesDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.ORCID 0009-0008-4207-2842
Sarah E FrazierDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.
Alexis RutledgeDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.
John F GriffinDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.ORCID 0000-0003-3943-7915
Soumiya PalDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212.ORCID 0000-0002-8003-9866
Scott ZawiejaDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212.ORCID 0000-0003-4658-3179
Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212.ORCID 0000-0002-7992-9300
Joseph M RutkowskiDepartment of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.
Peter P NghiemDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-8796-8123
Mendell RimerDepartment of Neuroscience and Experimental Therapeutics, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0009-0006-8441-1297
Mariappan MuthuchamyDepartment of Medical Physiology, Naresh K. Vashisht College of Medicine, Texas A&M University, Bryan, TX 77807.ORCID 0000-0002-5572-8563

Funding

Role of Skeletal Muscle Lymphatics in Duchenne Muscular Dystrophy RegulationR01AR080129 · NIAMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MARIAPPAN MUTHUCHAMY, Peter Phuong Nghiem · 2022 to 2026
$2.4M
Regulation of lymphatic muscle cell function by store operated calcium entry signalingR01HL175083 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Scott D. Zawieja · 2024 to 2026
$1.7M
LYMphatics in Pathology and Health (LYMPH)T32HL170975 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI BRETT M MITCHELL, MARIAPPAN MUTHUCHAMY · 2024 to 2026
$435k
American Heart Association (AHA) 25POST1378441HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL170975HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL175083HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR080129NHLBI NIH HHS R01 HL175083NHLBI NIH HHS T32 HL170975NIAMS NIH HHS R01 AR080129
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder characterized by progressive muscle weakness and inflammation caused by mutations in the DMD gene. Chronic inflammation in DMD exacerbates the complications associated with disease progression. Since the lymphatic system plays a crucial role in regulating and resolving inflammation, our primary goal was to investigate whether lymphatics were dysregulated in skeletal muscle of DMD animals. We used the

Indexed as

Lymphatic VesselsMuscular Dystrophy, DuchenneAnimalsDisease Models, AnimalDogsDystrophinLymphatic SystemMaleMiceMice, Inbred mdxMuscle, SkeletalRatsDystrophinDuchenne muscular dystrophyinflammationlymphatic musclelymphatic vessel functionlymph transport

Identifiers

PMID40966282
PMCPMC12478126

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.