Trial reportJournal of the International Society of Sports Nutrition2025
Effects of carbohydrate, caffeine, and combined mouth rinses on physiological and perceptual responses during high-intensity interval exercise following a pre-exercise meal: a double-blinded, placebo-controlled, randomized crossover trial.
Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Revisiting the evidence on caffeine mouth rinse: effects on exercise and cognitive performance: a meta-analytic review.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Energy Availability as a Neurocognitive Regulator of Endurance Performance: Integrating Metabolic, Perceptual, and Decision-Making Mechanisms-A Narrative Review.Sports (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMouth rinsing with carbohydrate (CHO), caffeine (CAF), and their combined (CHO+CAF) solutions has been shown to enhance exercise performance. However, most previous studies were conducted under fasted conditions, which may not accurately reflect the typical practices of athletes who generally consume food before intense exercise or competition. This study examined the effects of CHO, CAF, and CHO+CAF mouth rinses on physiological and perceptual responses during high-intensity interval exercise (HIIE) following a pre-exercise meal.
methodsTwelve recreationally active males (age: 23.4 ± 3.2 years) completed four HIIE trials involving 8 bouts of 1-min cycling at 85% of peak power output (PPO), separated by 1-min active recovery at 20% of PPO. Using a double-blinded randomized crossover design, participants rinsed with either 10% maltodextrin (CHO), 1.2% caffeine (CAF), 10% maltodextrin + 1.2% caffeine (CHO+CAF), or water (PLA) twice in each trial (after warm-up and interval 4). All solutions were taste-matched using the artificial sweetener sucralose. A standardized CHO-rich (1 g·kg
resultsRatings of perceived exertion were significantly different between conditions after interval 4 (CHO: 12.3 ± 1.6; CAF: 13.5 ± 2.2; CHO+CAF: 12.7 ± 1.7; PLA: 13.7 ± 2.4;
conclusionThese findings suggest a limited ergogenic benefit of CHO and/or CAF mouth rinse through physiological and perceptual responses following sufficient food intake.
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Registered trials
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