ArticleJournal of chemical information and modeling2025
Natural Products Repository of Costa Rica (NAPRORE-CR): An Open-Access Database.
Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Constellation Plots in KNIME: An Automated Scaffold-Based Workflow for Interactive Chemical Space Visualization.Molecular informatics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural products are outstanding sources of bioactive compounds with potential applications not only in drug discovery, but also in the cosmetic industry and natural pesticides. Costa Rica is among the most biologically diverse countries in terms of the number of known species per unit of area, even above conventionally considered megadiverse countries. In this work, we introduce the Natural Products Repository of Costa Rica (NAPRORE-CR), the first dedicated database that compiles structural representations and predicted properties of natural products found and/or characterized in Costa Rica. The first version of this collection comprises 1161 compounds, annotated with structural classifications, calculated structural and physicochemical properties (MW, HBD, HBA, RB, AlogP, and TPSA), and complex descriptors (SA score, QED, nSPS). The diversity and chemical space coverage of compounds in NAPRORE-CR were compared to drugs, pesticides, and cosmetics. Through the analysis and visualization of chemical space coverage and diversity, it was found that NAPRORE-CR has a property profile compatible with applications in all three fields and that its compounds are structurally similar to those of approved drugs and natural pesticides. Cross-referencing NAPRORE-CR with PubChem and ChEMBL, combined with activity predictions, facilitated the identification of both known applications of the included compounds and potential new areas of study. In favor of open science and FAIR principles for data sharing, NAPRORE-CR is freely available at 10.5281/zenodo.7858061.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.