ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Coagulation Biomarkers and Mortality in Severe COVID-19: The Prognostic Value of Factor XIII Decline and Elevated D-Dimers.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Unlucky for some? Bleeding associated with factor XIII deficiency during extracorporeal membrane oxygenation.Research and practice in thrombosis and haemostasis · 2026Article
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6 authors.
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Abstract
IntroductionThis study investigated the roles of d-dimers, fibrinogen, activated partial thromboplastin time (aPTT), and Factor XIII (FXIII) in critically ill COVID-19 patients.Methods68 patients were included into the study based on the inclusion criteria. Severe illness was defined as COVID-19 pneumonia leading to acute respiratory failure requiring mechanical ventilation and ICU (Intensive Care Unit) care. Patients who received Extracorporeal Membrane Oxygenation therapy were excluded due to its effects on the coagulation system. Blood samples were collected on day one and days five to seven, to measure coagulation parameters (aPTT, d-dimer, fibrinogen, and FXIII).ResultsIn total, 59% of the patients died during their hospital stay. Coagulation parameters showed elevated d-dimer levels in 95.6% of patients, while FXIII activity significantly decreased during the first week in ICU. A drop in FXIII activity over the first week (FXIII Δ) emerged as a significant predictor of in-hospital mortality (HR = 2.174,
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