ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025
Association between pilonidal sinus disease and depression: a population-based cohort study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Impact of Symptoms of Benign Anorectal Disorders on Self-Esteem and the Severity of Depression in Postpartum Women.Journal of clinical medicine · 2026Article
- The association between skin-suturing technique, prolonged healing and recurrence after Bascom's Cleft lift surgery.Techniques in coloproctology · 2026Article
- Incisional hernia and the risk of incident depression: a population-based propensity score-matched cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
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6 authors.
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Abstract
purposeThe aim of this study was to evaluate the association between pilonidal sinus disease (PSD) and the subsequent development of depression, addressing an unmet need to examine the psychosocial impact of PSD in a large, representative outpatient cohort in Germany.
methodsA retrospective cohort study was conducted using data from the IQVIA Disease Analyzer database, which contains anonymized medical records from 1,293 general practices across Germany. The study included patients aged ≥ 18 years diagnosed with PSD (ICD-10: L05) between 2005 and 2022, excluding those with pre-existing psychiatric conditions. Propensity score matching (5:1) was performed to pair PSD patients with individuals without PSD. Depression diagnoses (ICD-10: F32, F33) within five years after diagnosis were assessed using Kaplan-Meier curves and Cox regression analysis.
resultsA total of 11,245 PSD patients (23% women, mean age 35.3 years) were matched to individuals without PSD. The incidence of depression was higher in PSD patients (11.7%) compared to non-PSD cohort (10.5%) over five years (p < 0.001). PSD was associated with an increased risk of depression (HR: 1.16; 95% CI 1.09–1.24), with stronger associations observed in women (HR: 1.25; 95% CI 1.11–1.41) and patients > 45 years of age (HR: 1.44; 95% CI 1.26–1.64).
conclusionThis study demonstrates a significant association between PSD and depression, highlighting the need for integrated treatment approaches that address both physical and psychological aspects of PSD. Future research should further explore causal mechanisms and develop strategies for prevention and treatment of depression in PSD patients.
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