Evidence map›Paper›PMID 40965723›Full record

Trial reportHepatology international2026

Comparison of the impact of shunting the left versus right portal vein branch during TIPS on the postoperative overt hepatic encephalopathy: a randomized trial.

Yongjie Zhou, Jingqin Ma, Yaozu Liu, Li Ma, Jiaze Yu, Minjie Yang, Zhiping Yan, Wen Zhang, Jianjun Luo

Erratum issuedAbstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Hepatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yongjie Zhou *Department of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Jingqin Ma *Department of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Yaozu Liu *Department of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Li MaDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Jiaze YuDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Minjie YangDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Zhiping YanDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Wen ZhangDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. zhang.wen2@zs-hospital.sh.cn.
Jianjun LuoDepartment of Interventional Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. luo.jianjun@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0003-4942-0439

Funding

the Clinical Research Special Fund of Zhongshan Hospital, Fudan University 2018ZSLC23
6 · The paper itself

Abstract

BACKGROUND AND

aimThe effect of shunting the left or right branch of the portal vein on the post-transjugular intrahepatic portosystemic shunt (TIPS) hepatic encephalopathy (HE) remains controversial. Therefore, we designed this prospective, randomized, single-blinded trial to compare the incidence of HE after shunting the left or right branch of the portal vein during TIPS in cirrhotic patients to prevent variceal rebleeding.

methodsConsecutive patients diagnosed with hepatitis B virus (HBV)-related cirrhosis were randomly assigned in a 1:1 ratio to undergo the TIPS procedure, with the shunt directed to either the left or right branch of the portal vein. The primary outcome was the incidence of overt HE within 2 years. The secondary outcomes included shunt dysfunction, variceal rebleeding, survival, adverse events, and changes in liver function.

resultsBetween June 2019 and December 2020, 130 patients were randomly divided into two groups (left branch group vs right branch group). The 2-year cumulative incidence rates of free overt HE in the left branch group did not demonstrate statistical superiority over the right branch group (78.5% vs 68.6%, respectively; p = 0.236, HR = 1.49, 95% CI 0.76-2.93). Similarly, no statistical differences were observed in stent patency, all-cause bleeding, survival, or adverse events.

conclusionCompared to shunting the right branch of the portal vein, shunting the left branch during TIPS placement did not impact the incidence of post-TIPS HE and other clinical outcomes in cirrhotic patients to prevent variceal rebleeding. The choice of puncture site should be primarily guided by the patient's liver anatomy and the operator's experience.

Indexed as

Esophageal and Gastric VaricesHepatic EncephalopathyLiver CirrhosisPortal VeinPortasystemic Shunt, Transjugular IntrahepaticPostoperative ComplicationsAdultFemaleGastrointestinal HemorrhageHumansIncidenceMaleMiddle AgedProspective StudiesSingle-Blind MethodHepatic encephalopathyPortal hypertensionPortal vein branchTIPSVariceal bleeding

Identifiers

PMID40965723

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.