Observational studySleep & breathing = Schlaf & Atmung2025
Sleep patterns, genetic susceptibility, and gastrointestinal cancer mortality: a large-scale prospective cohort study.
Observational study in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe impact of sleep patterns on gastrointestinal cancer mortality has not been comprehensively explored. Moreover, the interaction between sleep patterns and genetic susceptibility with gastrointestinal cancer mortality remains uncertain.
methodsThe study included a total of 379 845 participants from the UK Biobank. A poor sleep pattern was defined by short sleep (< 7 h/day) or long sleep (> 9 h/day), late chronotype, frequent insomnia, snoring, and frequent daytime dozing. The outcomes were mortality of any gastrointestinal cancers and six site-specific gastrointestinal cancers. Polygenic risk score was generated to characterize genetic risk. Multivariable cox proportional hazards regression models were use to analyze the associations of sleep patterns and genetic susceptibility with gastrointestinal cancer mortality.
resultsA poor sleep pattern was associated with the increased risk of mortality from overall gastrointestinal cancer (HR 1.32, 95% CI 1.16-1.49), esophagus cancer (HR 1.37, 95% CI 1.02-1.85) and liver cancer (HR 2.01, 95% CI 1.48-2.74). Participants with a poor sleep pattern and high genetic risk combination had the highest mortality risks for esophagus, stomach, colorectal, and liver cancer. Significant multiplicative interactions (HR 1.51, 95% CI 1.05-2.18) and additive interactions (RERI 0.54, 95% CI 0.13-0.95; AP 0.34, 95% CI 0.10-0.58) of an intermediate sleep pattern and high genetic risk were observed on esophagus cancer mortality.
conclusionsA poor sleep pattern is associated with increased risks of gastrointestinal cancer mortality independent of the conventional risk factors, and the association is modified by genetic susceptibility.
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