ArticleUrolithiasis2025
Association between biological aging acceleration and kidney stone in Chinese adults: exploring the role of insulin resistance.
Article in Urolithiasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the triglyceride-glucose index and kidney stone disease: a systematic review and dose-response meta-analysis.Lipids in health and disease · 2026Pooled it
- Phenotypic age metrics for risk stratification of chronic disease burden and all-cause mortality in adults.Cardiovascular diabetology. Endocrinology reports · 2026Article
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5 authors.
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Abstract
Advanced biological aging is linked to a higher risk of adverse health outcomes; however, its association with kidney stone (KS) remains unclear. This cross-sectional study investigated the relationship between biological aging acceleration (BAA) and KS, along with the potential mediating role of insulin resistance, in 18,868 Chinese adults aged 20-80 years undergoing health examinations at Ruijin Hospital between 2020 and 2024. Biological age was assessed using the Klemera-Doubal method biological age (KDM-BA) and Phenotypic age(PhenoAge) algorithms, with BAA calculated via residual analysis relative to the chronological age. Insulin resistance(IR) was evaluated using surrogate indices including the triglyceride glucose index (TyG), TyG-body mass index (TyG-BMI), and metabolic score for insulin resistance (METS-IR). The overall prevalence of KS was 5.25%. After full covariate adjustment, participants in the highest quintile of KDM-BA acceleration had a 1.34-fold higher risk of KS than those in the lowest quintile (95% confidence interval [CI]: 1.05-1.70). Similarly, those in the highest PhenoAge acceleration quintile exhibited a 1.39-fold increase in KS risk (95% CI: 1.10-1.76). KDM-BA and PhenoAge acceleration increased by 12% (odds ratio[OR]: 1.12, 95% CI: 1.04-1.20) and 9% (OR: 1.09, 95% CI: 1.03-1.16) per standard deviation, respectively, in correlation with higher KS risk. Restricted cubic spline analysis confirmed dose-response relationships for both KDM-BA (P-
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