Evidence map›Paper›PMID 40965633›Full record

ReviewPathologie (Heidelberg, Germany)2025

[Hepatitis diagnostics : Differential diagnosis of viral hepatitis from other causes of elevated transaminases].

Beate K Straub, Christian Labenz, Achim Weber, Uta Drebber

Abstract readReviewEnglish Abstract
PubMed Publisher
In one paragraph

Review in Pathologie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Beate K StraubInstitut für Pathologie, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland. beate.straub@unimedizin-mainz.de.ORCID http://orcid.org/0000-0002-4857-1561
Christian Labenz1. Medizinische Klinik, Universitätsmedizin Mainz, Mainz, Deutschland.
Achim WeberInstitut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Zürich, Schweiz.
Uta DrebberInstitut für Pathologie, Universitätsklinik Köln, Köln, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver biopsies in unclear hepatitis are required to assess etiology together with the clinico-serological findings to differentiate comorbidities. In addition, inflammatory activity should be graded, extent of necrosis estimated, and the stage of fibrosis determined in order to estimate pre-existing parenchymal damage. In liver biopsies from patients with acute liver failure, drug-induced liver injury, most often in idiosyncrasy is most common. While a liver biopsy is required for the diagnosis of autoimmune hepatitis, the diagnosis of viral hepatitis A-D is usually made clinically and serologically. Yet, hepatitis E is often underestimated: in addition to acute hepatitis in immunocompetent patients, hepatitis E-virus (HEV) infection may also manifest with a fulminant course in patients with pre-existing liver cirrhosis and follow a chronic course in immunocompromised patients.

Indexed as

Hepatitis, Viral, HumanTransaminasesBiopsyChemical and Drug Induced Liver InjuryDiagnosis, DifferentialHepatitis, AutoimmuneHepatitis EHumansLiverLiver CirrhosisTransaminasesAutoimmune HepatitisDrug-induced liver injuryHepatitis ELiver biopsySteatohepatitis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.