Evidence map›Paper›PMID 40965610›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Analysis of risk factors for otitis media in hospitalized children aged ≤ 12 years with bacterial pneumonia.

Liyuan Han, Jie Liu, Yanhua Li, Minglei Liu, Huimiao Liu, Jinghua Wu, Chunyan Gao

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Liyuan HanClinical Laboratory, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China.
Jie LiuOtorhinolaryngology Head and Neck Surgery, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China.
Yanhua LiClinical Laboratory, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China.
Minglei LiuClinical Laboratory, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China.
Huimiao LiuClinical Laboratory, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China.
Jinghua WuClinical Laboratory, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China.
Chunyan GaoClinical Laboratory, Tangshan Municipal Women and Children's Hospital, 063000, Tangshan, Hebei, China. gcy3726694@126.com.

Funding

Medical Science Research Project of Hebei 20231759
6 · The paper itself

Abstract

backgroundTo analyze the risk factors for otitis media in children aged ≤ 12 years who develop the condition after being hospitalized for bacterial pneumonia.

methodsA total of 411 hospitalized patients aged ≤ 12 years with bacterial pneumonia, admitted between November 2023 and March 2025, were included. Demographic data, birth history, feeding history, and laboratory indicators were recorded to assess their connection with the development of otitis media after hospitalization. First, univariate logistic regression was performed, followed by multivariate logistic regression using a backward stepwise method to establish the final predictive model. The model's effectiveness was assessed based on the AUC (area under the ROC curve), calibration plots, and decision curve analysis (DCA).

resultsPatients were stratified into two groups based on the occurrence of otitis media: the non-otitis media group (n = 303) and the otitis media group (n = 108). The study found that several factors were significantly associated with the risk of developing otitis media in children hospitalized with bacterial pneumonia: age 3-12 years (OR: 0.51, 95%CI: 0.26-0.97, p = 0.012), infection with Haemophilus influenzae (HI) (OR: 1.91, 95%CI: 1.07-3.42, p = 0.027), antibiotic use prior to admission (OR: 2.54, 95%CI: 1.29-5.27, p = 0.009), platelet count (OR: 1.00, 95%CI: 1.00- 1.01, p = 0.002), hemoglobin level (OR: 0.95, 95%CI: 0.93-0.98, p < 0.001), alanine aminotransferase (ALT) (OR: 1.04, 95%CI: 1.01-1.07, p = 0.019), creatine kinase (CK) (OR: 1.02, 95%CI: 1.01-1.04, p < 0.001), lactate dehydrogenase (OR: 1.00, 95%CI: 1.00-1.01, p = 0.049). The final model showed that age ≤ 3 years, HI infection, take antibiotics, higher monocyte count, higher PLT, lower HGB, higher ALT, higher CK and LDH were risk factors for OM.

conclusionThe results emphasize the role of demographic characteristics, birth history, feeding history, and laboratory indicators in the risk of developing otitis media during hospitalization in children aged ≤ 12 years with bacterial pneumonia. Incorporating these risk factors into clinical practice may enhance early identification, guide targeted prevention strategies, and ultimately improve outcomes in high-risk populations.

Indexed as

Otitis MediaPneumonia, BacterialChildChild, HospitalizedChild, PreschoolFemaleHaemophilus InfectionsHospitalizationHumansInfantLogistic ModelsMaleRetrospective StudiesRisk FactorsBacterial pneumoniaHI infectionOtitis mediaPredictive modelingRisk factors

Identifiers

PMID40965610

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