Evidence map›Paper›PMID 40965589›Full record

Observational studyAntimicrobial agents and chemotherapy2025

Comparison of early treatment with ceftolozane/tazobactam versus polymyxin-based therapy of pneumonia due to MDR

Thomas P Lodise, Jae Min, Brian H Nathanson, Emre Yücel

Abstract readObservational StudyComparative StudyMulticenter Study
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Global epidemiology of carbapenem-resistantJAC-antimicrobial resistance · 2026
    Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas P LodisePharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.ORCID 0000-0002-4730-0655
Jae MinMerck & Co., Inc., Rahway, New Jersey, USA.
Brian H NathansonOptiStatim LLC, Longmeadow, Massachusetts, USA.
Emre YücelMerck & Co., Inc., Rahway, New Jersey, USA.

Funding

Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.
6 · The paper itself

Abstract

Ceftolozane/tazobactam and polymyxin-based regimens are frequently used to treat pneumonia caused by multi-drug-resistant

Indexed as

Anti-Bacterial AgentsCephalosporinsPneumonia, BacterialPolymyxinsPseudomonas aeruginosaPseudomonas InfectionsTazobactamAgedAged, 80 and overCOVID-19Drug Resistance, Multiple, BacterialFemaleHumansMaleMiddle AgedTreatment OutcomeAnti-Bacterial Agentsceftolozane, tazobactam drug combinationCephalosporinsPolymyxinsTazobactamceftolozane/tazobactamDOORoutcomespolymyxinPseudomonas

Identifiers

PMID40965589
PMCPMC12587572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.