Evidence map›Paper›PMID 40965572›Full record

ReviewClinical reviews in allergy & immunology2025

Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies.

Jiani Chen, Chen Zhang, Qianqian Zhang, Fuying Cheng, Yizhang Wang, Shirui Xue, Yufei Yang, Wenwen Guo, Juan Liu, Kai Xue and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiani ChenHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Chen ZhangHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Qianqian ZhangHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Fuying ChengHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Yizhang WangHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Shirui XueHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Yufei YangHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Wenwen GuoHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Juan LiuHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Kai XueHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Yaguang ZhangCenter for Immunological and Metabolic Diseases, the First Affiliated Hospital of Xi'an JiaoTong University, JiaoTong University, Xi'an, Shaanxi, China.
Dehui WangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, 200031, China.
Li HuHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Huan WangHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Xicai SunHigh Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. laryngeal@163.com.

Funding

Natural Science Foundation of China 82460220Natural Science Foundation of Shanghai 21ZR1411700Natural Science Foundation of Shigatse(Joint Project) RKZ2023ZR-008(Z)Natural Science Foundation of Tibet Autonomous Region XZ202401ZR0046
6 · The paper itself

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.

Indexed as

Interleukin-13Interleukin-4Nasal PolypsRhinitisSignal TransductionSinusitisAnimalsChronic DiseaseHumansMolecular Targeted TherapyRhinosinusitisIL4 protein, humanInterleukin-13Interleukin-4Chronic rhinosinusitis with nasal polypsInterleukin-13Interleukin-4Type 2 inflammation

Identifiers

PMID40965572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.