Evidence map›Paper›PMID 40965523›Full record

ArticleCerebellum (London, England)2025

Longitudinal Study and Characterization of Gait Impairment in a Mouse Model of SCA1.

Siddhartha Maharjan, Eliyahu Kochman, Tatiana Gervase, Nina Page, Mannut Singh, Rajveer Singh, Avani Chitnis, Ashka Shah, Sidharth Addepalli, Ria Paradkar and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Siddhartha MaharjanDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Eliyahu KochmanDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Tatiana GervaseDepartment of Anatomical Sciences and Neurobiology, University of Louisville, 511 S. Floyd St. Room 111, Louisville, KY, 40202, USA.
Nina PageDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Mannut SinghDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Rajveer SinghDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Avani ChitnisDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Ashka ShahDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Sidharth AddepalliDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Ria ParadkarDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Rishika ChavaliDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Hana MirDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Anna ZhengDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Lydia SteenmanDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA.
Hannah ShorrockDepartment of Biology and RNA Institute, State University of New York at Albany, Albany, NY, USA.
Andrew BerglundDepartment of Biology and RNA Institute, State University of New York at Albany, Albany, NY, USA.
Vinata Vedam-MaiDepartment of Neurosurgery, University of Florida, Gainesville, FL, USA.
Damian ShinDepartment of Neuroscience and Experimental Therapeutics, Albany medical College, 47 New Scotland Ave, Albany, NY, 12208, USA. damian.shin@louisville.edu.

Funding

Alternative Splicing and Development of Small Molecule Therapeutics in CAG Expansion Spinocerebellar AtaxiasR01NS135254 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Andrew Berglund, Damian Seung-Ho Shin · 2024 to 2026
$2.0M
Dentatothalamocortical circuit and its neuromodulation in Spinocerebellar ataxiasR21NS114794 · NINDS · ALBANY MEDICAL COLLEGE · PI SHIN, DAMIAN SEUNG-HO, VEDAM-MAI, VINATA · 2020 to 2020
$407k
NIH HHS 1R01NS135254-01NIH HHS 1R21NS114794-01A1NINDS NIH HHS R01 NS135254NINDS NIH HHS R21 NS114794
6 · The paper itself

Abstract

Spinocerebellar ataxia 1 (SCA1) is a rare autosomal dominant neurodegenerative disease characterized by impaired gait, coordination, and balance. SCA1 results from an expanded CAG repeat in the Atxn1 gene, inducing protein aggregation and ultimately leading to the degeneration of cerebellar Purkinje cells. Clinical studies have shown that gait impairments, such as changes in stride length (SL), stride time, and stance phase, are seen in patients with cerebellar diseases. The SCA1

Indexed as

GaitGait Disorders, NeurologicSpinocerebellar AtaxiasAnimalsAtaxin-1Disease Models, AnimalDisease ProgressionFemaleGait AnalysisLongitudinal StudiesMaleMiceMice, Inbred C57BLMice, TransgenicAtaxin-1Atxn1 protein, mouseBehavioral testingCerebellumDigiGaitHindlimb claspingSex differencesSpinocerebellar ataxia 1

Identifiers

PMID40965523
PMCPMC12446116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.