Evidence map›Paper›PMID 40965512›Full record

ArticleAntimicrobial agents and chemotherapy2025

Deconvoluting drug interactions using

Elizabeth A Wynn, Christian Dide-Agossou, Reem Al Mubarak, Karen Rossmassler, Jo Hendrix, Martin I Voskuil, Andrés Obregón-Henao, Michael A Lyons, Gregory T Robertson, Camille M Moore and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Adaptive immunity shapes baseline physiology ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizabeth A WynnCenter for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.ORCID 0000-0002-5857-4483
Christian Dide-AgossouRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.
Reem Al MubarakRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.
Karen RossmasslerRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.
Jo HendrixRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.ORCID 0000-0001-9029-2390
Martin I VoskuilConsortium for Applied Microbial Metrics, Aurora, Colorado, USA.
Andrés Obregón-HenaoMycobacteria Research Labs, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Michael A LyonsConsortium for Applied Microbial Metrics, Aurora, Colorado, USA.ORCID 0000-0003-0143-6626
Gregory T RobertsonConsortium for Applied Microbial Metrics, Aurora, Colorado, USA.ORCID 0000-0001-7157-4034
Camille M Moore *Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.
Nicholas D Walter *Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.ORCID 0000-0003-0126-1993

Funding

Preclinical Design and Clinical Translation of TB Regimens (PReDicTR) ConsortiumUM1AI179699 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kelly E. Dooley, ERIC L NUERMBERGER · 2024 to 2026
$22.2M
Improving combination chemotherapy of tuberculosis: a computational approachR01AI125454 · NIAID · COLORADO STATE UNIVERSITY · PI LYONS, MICHAEL A. · 2016 to 2020
$2.7M
Bill and Melinda Gates Foundation OPP1170003BLRD VA I01 BX004527Gates Foundation INV-009105NIAID NIH HHS R01 AI125454NIAID NIH HHS UM1 AI179699NIH HHS R01AI125454NIH HHS UM1AI179699Veterans Affairs 1I01BX004527-01A1
6 · The paper itself

Abstract

A key challenge in preclinical tuberculosis drug development is identifying optimal antibiotic combinations. Drug interactions are complex because one drug may affect

Indexed as

Antitubercular AgentsDiarylquinolinesLinezolidMycobacterium tuberculosisTuberculosisAnimalsDrug InteractionsDrug Therapy, CombinationFemaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsNitroimidazolesAntitubercular AgentsbedaquilineDiarylquinolinesLinezolidNitroimidazolespretomanidantibiotic exposureantibiotic interactionM. tuberculosisRNA sequencing

Identifiers

PMID40965512
PMCPMC12587609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.