ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults.npj aging · 2026Article
- Article
- Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Exercise-induced modulation of astrocyte in Alzheimer's disease: mechanisms and therapeutic implications.Frontiers in physiology · 2026Review
- Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
introductionPhysical activity is linked to lower dementia risk, but its connection to Alzheimer's disease (AD) pathology remains uncertain. This study examined the relationship between objectively measured physical activity and early AD biomarkers in cognitively unimpaired adults.
methodsAccelerometer-measured physical activity and plasma AD biomarkers (beta-amyloid [Aβ]42/Aβ40, p-tau217) were assessed in 242 participants (age = 63.37 [54-79] years) of the population-based Rotterdam Study. Cortical Aβ was assessed via
resultsPhysical activity was not associated with plasma Aβ42/Aβ40, p-tau217, or brain Aβ burden 7 years later. Reallocating awake sedentary time to physical activity showed no association with AD biomarkers. DISCUSSION: No relationship was identified between physical activity and AD biomarkers, suggesting physical activity might affect dementia risk through other pathways or in an earlier life phase. HIGHLIGHTS: Physical activity was not associated with plasma beta-amyloid (Aβ)42/Aβ40 nor p-tau217. No association was observed between physical activity and brain Aβ 7 years later. Age, sex, and apolipoprotein E ε4 carriership did not moderate these relationships. Reallocating 30 minutes of sedentary time to physical activity resulted in no change in Alzheimer's disease (AD) biomarkers.
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