Evidence map›Paper›PMID 40965428›Full record

ArticleActa anaesthesiologica Scandinavica2025

Selected Serious Adverse Events in a Cohort of Adult ICU Patients: Protocol for a Sub-Study of the PATIENCE Cohort.

Vera Crone, Morten Hylander Møller, Anders Granholm, Anders Perner, Waleed Alhazzani, Abdulrahman Al-Fares, Johanna Hästbacka, Marlies Ostermann, Carmen A Pfortmueller, Ricard Ferrer and 4 more

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Article in Acta anaesthesiologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vera CroneDepartment of Intensive Care, Holbæk Hospital, Holbæk, Denmark.
Morten Hylander MøllerDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-6378-9673
Anders GranholmDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-5799-7655
Anders PernerDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Waleed AlhazzaniScientific Research Centre, Ministry of Defence Health Services, Riyadh, Saudi Arabia.
Abdulrahman Al-FaresDepartment of Anaesthesia, Critical Care Medicine and Pain Medicine, Al-Amiri Hospital, Ministry of Health, Kuwait City, Kuwait.
Johanna HästbackaDepartment of Intensive Care, Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Tampere University, Tampere, Finland.
Marlies OstermannDepartment of Critical Care, King's College London, Guy's and St. Thomas' Hospital, London, UK.ORCID 0000-0001-9500-9080
Carmen A PfortmuellerDepartment of Intensive Care, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Ricard FerrerVall D'hebron Hospital Universitari, Vall D'hebron Barcelona Hospital Campus, Barcelona, Spain.
Annika Reintam BlaserDepartment of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1211-7372
Eric KeusDepartment of Critical Care, University Medical Center Groningen, Groningen, the Netherlands.
Wojciech SzczeklikCenter for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krakow, Poland.
Mette KragDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerious adverse events (SAEs) are a relevant patient safety concern in critically ill patients, yet epidemiological data on their occurrence in the intensive care unit (ICU) remain limited. This sub-study of the PATIENCE cohort study aims to describe the occurrence of selected SAEs in adult ICU patients with and without prokinetic treatment.

methodsThis is a protocol and statistical analysis plan for a post hoc sub-study of the "Prokinetic agents in adult intensive care unit patients-An international inception cohort study (PATIENCE)" which has included 1440 acutely admitted adult ICU patients from 11 countries. The primary outcome is the proportion of patients experiencing selected SAEs, assessed according to exposure to prokinetic treatment. Secondary outcomes include the proportion of patients experiencing each specific SAE, their distribution by treatment duration, and timing in relation to ICU admission and prokinetic use. Furthermore, patient characteristics for those with and without the SAEs will be described. Data will be presented descriptively.

conclusionThis sub-study will use data from the international PATIENCE cohort study to provide epidemiological data on the occurrence of SAEs potentially related to prokinetic use in adult ICU patients.

Indexed as

Critical CareGastrointestinal AgentsIntensive Care UnitsAdultCohort StudiesCritical IllnessFemaleHumansMaleGastrointestinal Agents

Identifiers

PMID40965428
PMCPMC12445326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.