Evidence map›Paper›PMID 40965224›Full record

ArticleJournal of bacteriology2025

Molecular interplay between peptidoglycan integrity and outer membrane asymmetry in maintaining cell envelope homeostasis.

Sinjini Nandy, Arshya F Tehrani, Augusto C Hunt-Serracin, Jacob Biboy, Christine Pybus, Waldemar Vollmer, Joseph M Boll

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sinjini NandyDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.ORCID 0009-0009-1348-0879
Arshya F TehraniDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Augusto C Hunt-SerracinDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Jacob BiboyCentre for Bacterial Cell Biology, Newcastle University, Newcastle upon Tyne, England, United Kingdom.
Christine PybusDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Waldemar VollmerCentre for Bacterial Cell Biology, Newcastle University, Newcastle upon Tyne, England, United Kingdom.
Joseph M BollDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.ORCID 0000-0003-1412-9780

Funding

Mechanistic basis of how LD-transpeptidases protect against outer membranedefectsR01AI168159 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI Joseph Michael Boll · 2022 to 2026
$2.3M
Reinforcing the barrier: Understanding how cell envelope modifications promote intrinsic antimicrobial tolerance and resistance in Acinetobacter baumanniiR35GM143053 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI BOLL, JOSEPH MICHAEL · 2021 to 2025
$1.9M
Biotechnology and Biological Sciences Research Council BB/W013630/1National Institute of Allergy and Infectious Diseases R01AI168159NIAID NIH HHS R01 AI168159NIGMS NIH HHS R35 GM143053NIGMS NIH HHS R35GM143053
6 · The paper itself

Abstract

The bacterial cell envelope is a critical interface with the environment, particularly in Gram-negative species where the outer membrane (OM) and peptidoglycan (PG) layers coordinate to maintain structural integrity and resist turgor. Although this coordination is essential for survival, the molecular mechanisms linking OM and PG homeostasis remain poorly understood. LD-transpeptidases (LDTs) are enzymes that crosslink peptides in PG and incorporate d-amino acids, but their physiological roles are not fully defined. Here, we characterize the activity of the LDT enzyme LdtJ in

Indexed as

Acinetobacter baumanniiBacterial Outer MembraneCell MembraneCell WallHomeostasisPeptidoglycanBacterial Outer Membrane ProteinsBacterial ProteinsGene Expression Regulation, BacterialPeptidyl TransferasesBacterial Outer Membrane ProteinsBacterial ProteinsPeptidoglycanPeptidyl Transferasescell envelopegram-negative bacteriaLD-transpeptidasemaintenance of lipid asymmetrypeptidoglycan

Identifiers

PMID40965224
PMCPMC12548408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.