Evidence map›Paper›PMID 40964844›Full record

ReviewAnnals of neurology2025

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases.

Nico J Diederich, Martin Brüne, John S Allen, Nicole Bender, Emiliano Bruner, Jean-Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka and 11 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nico J Diederich *Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg.ORCID 0000-0001-8537-8595
Martin Brüne *LWL University Hospital Bochum, Department of Psychiatry, Psychotherapy and Preventive Medicine, Division of Social Neuropsychiatry and Evolutionary Medicine, Ruhr University Bochum, Bochum, Germany.
John S AllenDepartment of Anthropology, Indiana University, Bloomington, IN, USA.
Nicole BenderClinical Evolutionary Medicine Group, Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland.
Emiliano BrunerMuseo Nacional de Ciencias Naturales, CSIC, Madrid, Spain.
Jean-Pierre ChangeuxInstitut Pasteur and Collège de France, Paris, France.
Corrado CaliDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.ORCID 0000-0003-4856-0835
Olga DolgovaDepartment of Genetics and Microbiology, Universitat Autonoma de Barcelona, Barcelona, Spain.ORCID 0000-0001-5231-9388
Anne GrünewaldLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-4179-2994
Geneviève KonopkaDepartment of Neuroscience, University of Texas Southwestern Medical Centre, Dallas, TX, USA.
Peng JinDepartment of Human Genetics, Emory University, Atlanta, GA, USA.
Roger LemonDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Gilberto LevyIndependent researcher, Rio de Janeiro, Brazil.
Pierre MagistrettiBiological and Environmental Sciences and Engineering Department, KAUST, Thuwal, Saudi Arabia.
Markus J RantalaDepartment of Biology, University of Turku, Turku, Finland.
Kathleen S RocklandDepartment of Anatomy & Neurobiology, Boston University, Boston, MA, USA.
Roger SullivanDepartment of Anthropology, California State University, Sacramento, CA, USA.
Annie SwanepoelNortheast London NHS Foundation Trust, Chelmsford, UK.
Toshiki UchiharaOkinawa Chubu Hospital, Okinawa, Japan.
Katrin Amunts *Cecile and Oskar Vogt Institute for Brain Research, Heinrich-Heine University, Düsseldorf, Germany.
Christopher G Goetz *Department of Neurological Sciences, Rush University Medical Centre, Chicago, IL, USA.ORCID 0000-0003-1665-8205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease. Here, we discuss evolutionary concepts relevant to understanding human brain diseases, on the genetic, subcellular, cellular, connectomic, behavioral, and cultural levels. By revisiting common neurological diseases, we discuss evolved residues from our ancestors, mechanisms of exaptation, antagonistic pleiotropy, and human longevity with the consequent outpacing of biological evolution by cultural evolution. An evolution-based conceptual framework can propel transdisciplinary research targeting the constraints imposed by and compensatory adaptations involved in human-specific neurological diseases. ANN NEUROL 2025;98:1178-1195.

Indexed as

Biological EvolutionBrain DiseasesAnimalsBrainHumans

Identifiers

PMID40964844
PMCPMC12682948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.