ReviewACS synthetic biology2025
Broad-Host-Range Synthetic Biology: Rethinking Microbial Chassis as a Design Variable.
Review in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Snapshot at Saccharomycopsis fibuligera metabolism for industrial terpenoid production and bioengineering.BMC microbiology · 2026Article
- Evaluating isoprenol production using the IPP-bypass pathway in the oleaginous yeast Rhodosporidium toruloides.Biotechnology for biofuels and bioproducts · 2026Article
- Genome minimization of a Burkholderia bacterial host.Metabolic engineering · 2026Article
- Expanding the genetic toolset: using serine recombinases to integrate riboregulatory elements into industrially relevant microbial chassis.Journal of industrial microbiology & biotechnology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Broad-host-range synthetic microbiology is redefining the role of microbial hosts in genetic design by moving beyond the traditional organisms. Historically, synthetic biology has focused on optimizing engineered genetic constructs within a limited set of well-characterized chassis, often treating host-context dependency as an obstacle. However, emerging research demonstrates that host selection is a crucial design parameter that influences the behavior of engineered genetic devices through resource allocation, metabolic interactions, and regulatory crosstalk. By leveraging microbial diversity, broad-host-range synthetic biology enhances the functional versatility of engineered biological systems, enabling a larger design space for biotechnology applications in biomanufacturing, environmental remediation, and therapeutics. The continued development of broad-host-range tools─including modular vectors and host-agnostic genetic devices─facilitates the expansion of chassis selection, improving system predictability and stability. This perspective highlights the advantages of incorporating host selection into synthetic biology design principles, positioning microbial chassis as tunable components rather than passive platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.