ArticleClinical toxicology (Philadelphia, Pa.)2025
Pupillary dynamics as a marker of acute cannabis inhalation.
Article in Clinical toxicology (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
introductionAcute cannabis use has been found to affect pupil size and pupillary dynamics. Law enforcement may consider ocular changes in their examinations to determine drug impairment and the source, including from cannabis. A limited number of studies have used pupillometer technology to provide an objective measure of pupillary changes associated with cannabis use. The purpose of the study was to examine the sensitivity and specificity of pupil size and dynamics, measured with a pupillometer, associated with recent cannabis inhalation.
methodsParticipants (
resultsFollowing cannabis use, the pupillary measure with the highest area under the curve was percent change in pupil size, which decreased after cannabis use, with an area under the curve of 0.73 at 40 min and 0.75 at 100 min following cannabis use. Considering variables together in a least absolute shrinkage and selection operator model did not meaningfully improve prediction over individual measures. DISCUSSION: Consistent with some prior studies, we did not find that cannabis use was associated with substantial and consistent change in the maximum pupil size (measured in darkness) relative to controls. However, diminished pupil dynamics, such as constriction in response to light and recovery dilation, were more predictive of recent cannabis use, consistent with limited prior studies.
conclusionsPupillary dynamics, when measured with an objective test, may contribute to providing an indication of recent cannabis inhalation.
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