Evidence map›Paper›PMID 40964745›Full record

ArticleAdvanced biology2025

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study.

Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Britta EggersMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.ORCID 0000-0002-6553-4631
Maximilian HausherrMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.
Michel LimMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.
Karin SchorkMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.
Bilhan KaracoraMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.
Robin GrugelMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.
Martin EisenacherMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.
Isabel Gil AldeaNavarrabiomed Biobank, Hospital, Universitario de Navarra, Pamplona, 31008, Navarra, Spain.
Peter RiedererUniversity Hospital Wuerzburg, Center of Mental Health, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, Margarete-Hoeppel-Platz 1, D-97080, Wuerzburg, Germany.
Manfred GerlachCenter of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, University of Wuerzburg, 97080, Wuerzburg, Germany.
Katrin MarcusMedizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801, Bochum, Germany.

Funding

Bundesministerium für Bildung und Forschung W-de.NBI-005Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-WestfalenMinisterium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen 233-1.08.03.03-031Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen 68079Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen 111.08.03.05-133974
6 · The paper itself

Abstract

Physiological aging is accompanied by structural and molecular changes in the brain, with varying degrees in different brain areas, and is considered one of the major risk factors for neurodegenerative diseases. Thus, the present study focuses on elucidating age-related changes in the substantia nigra pars compacta (SNpc), a brain region particularly vulnerable in Parkinson's disease. Here, the aim is to gain a spatially resolved view of aging-dependent alterations to conclude early processes potentially involved in neurodegeneration. Neuromelanin granules and SNpc tissue are isolated from tissue samples of young and elderly individuals via laser microdissection and measured by mass spectrometry to ascertain changes in protein expression in response to age. The findings include the identification of reduced levels of proteins involved in dopaminergic neurotransmission, either suggesting a specific loss of dopaminergic neurons or a reduction in metabolic activity. Furthermore, increased neuroinflammation is observed in elderly individuals and alterations in vesicular trafficking as well as mitochondrial proteins. Consequently, this exploratory study suggests that alterations causing known pathomechanisms of Parkinson's disease are already occurring in the physiological aging process. Since aging is still the most important risk factor for neurodegenerative diseases, these findings strengthen the necessity for studying age-related changes.

Indexed as

AgingProteomeProteomicsSubstantia NigraAdultAgedAged, 80 and overDopaminergic NeuronsFemaleHumansMaleMelaninsMiddle AgedParkinson DiseaseYoung AdultMelaninsneuromelaninProteomebrain agingdementia with Lewy bodiesneuromelanin granulesParkinson's diseaseproteomics

Identifiers

PMID40964745
PMCPMC12712771

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.