ReviewFrontiers in nutrition2025
Interplay between dietary nitrate metabolism and proton pump inhibitors: impact on nitric oxide pathways and health outcomes.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations.International journal of molecular sciences · 2026Review
- Life-Course Regulation of Health and Disease by Nitric Oxide: Mechanistic Insights.Antioxidants (Basel, Switzerland) · 2026Review
- In Vivo Studies on the Interaction Between Orally Administered Nitrite and Omeprazole: Beyond Proton-Catalyzed S-Nitrosation.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton-pump inhibitors (PPIs) are often-prescribed antacids that are useful in the treatment of gastrointestinal disorders. Nonetheless, a number of studies have raised concerns about their long-term use, linking them to a higher risk of cardiovascular disease and other possible adverse effects, including brain damage. Since nitric oxide (NO) plays a vital role in neurological and vascular health, it is important to look into how PPIs might change the NO pathway. Oral bacteria and the preservation of a healthy stomach environment are essential for the external pathway's synthesis of NO, which involves dietary nitrates (NO₃
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Registered trials
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