Evidence map›Paper›PMID 40964684›Full record

ArticleFrontiers in nutrition2025

Dietary flavonoids form supramolecular assemblies, alter biochemistry, and enhance cell resilience.

Charles B Reilly, Sylvie G Bernier, Sanjid Shahriar, Viktor Horvath, Michael Lewandowski, Emilia Javorsky, Bogdan Budnik, Donald E Ingber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charles B ReillyWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Sylvie G BernierWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Sanjid ShahriarWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Viktor HorvathWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Michael LewandowskiWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Emilia JavorskyWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Bogdan BudnikWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.
Donald E IngberWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonoids, a diverse class of polyphenols found in many plant-based foods, are increasingly recognized for their health benefits, including antioxidant and anti-inflammatory activities. Recent evidence links higher dietary flavonoid diversity with reduced all-cause mortality and improved outcomes in chronic diseases. Yet, due to concerns about non-specific binding, their exclusion from drug development pipelines has limited deeper mechanistic understanding. Here, we show how flavonoids may promote cellular resilience by forming supramolecular assemblies that interact with proteins. Using molecular dynamics simulations (MDS) and

Indexed as

flavonoidsmolecular dynamic simulation (MDS)polyphenolsradiationsupramolecular assembly

Identifiers

PMID40964684
PMCPMC12439166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.