ReviewFrontiers in microbiology2025
Berberine and its nanoformulations and extracts: potential strategies and future perspectives against multi-drug resistant bacterial infections.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Polyendocrine Metabolic Ovarian Syndrome (PMOS; Formerly Polycystic Ovary Syndrome/PCOS) and Susceptibility to Microbial Infections: Mechanisms, Clinical Management, and Reproductive Consequences - A Comprehensive Review.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Berberine Hydrochloride Attenuates Growth, Biofilm Formation, and Virulence Associated Phenotypes of Actinobacillus pleuropneumoniae Strain APP-2023.Current microbiology · 2026Article
- Berberine Synergistically Enhances the Antibacterial Activity of Ampicillin against Ampicillin-ResistantACS omega · 2026Article
- Pipa Qingfei Yin Ameliorates Acne Inflammation in Mice via Suppressing Neutrophil Extracellular Traps.Microbiology and immunology · 2026Article
- Natural Products as Nutritional Supplements in Human Disease Prevention and Management: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Antibacterial Activity of Berberine AgainstBiology · 2026Article
- Targeting the Microbiota-Gut-Brain Axis: Emerging Nanomedicine Approaches for Neurodegenerative Diseases.The European journal of neuroscience · 2026Review
- Berberine Attenuates Chromobacterium violaceum's Virulence by Targeting Efflux and Denitrification Machinery.Chemistry & biodiversity · 2026Article
- Integrated Transcriptome and Metabolome Analysis Reveals Differential Berberine Biosynthesis in Leaves and Stems ofCurrent issues in molecular biology · 2026Article
- Berberine Toxicity Profile in Experimental Models as a Basis for Assessing Its Biological Safety.Molecules (Basel, Switzerland) · 2026Article
- Synergistic Effect of the Mucosa-Friendly Agents Berberine and Tea Tree Oil on Mucosal Protection AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Article
- Enhanced controlled drug delivery of berberine-loaded gelatin nanoparticles: characterization andRSC advances · 2026Article
- Medicinal plants as biological and socio-ecological components of One Health.Frontiers in pharmacology · 2026Review
- Sequential eradication of bacterial persisters: integrating phytochemical pharmacology with microenvironment-responsive delivery strategies.Frontiers in microbiology · 2026Review
- Potential of isoquinoline-alkaloid-richFrontiers in pharmacology · 2026Article
- An updated overview of alkaloids for the prevention and treatment of metabolic dysfunction-associated steatotic liver disease.Frontiers in pharmacology · 2026Review
- Effects of dietary berberine hydrochloride on growth, immunity, meat quality, and fecal microbiota in broiler chickens.Frontiers in veterinary science · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing prevalence of antimicrobial resistance (AMR) has led to the gradual decline in the effectiveness of existing antibiotics, posing a significant threat to global health. Many phytochemicals have antimicrobial activity, but few have been developed for clinical use. Berberine, an alkaloid found in various medicinal plants, has been recognized as a promising strategy to combat AMR due to its notable antimicrobial activity and role in reversing resistance. Here, we present a systematic, comprehensive and objective overview of the antimicrobial activity, mechanism of action, and limitations of berberine. Additionally, we discuss the antimicrobial efficacy of berberine extracts and nanoformulations. Berberine demonstrates broad-spectrum antimicrobial activity by inhibiting FtsZ, disrupting cell membranes and cell walls, and interfering with DNA and RNA synthesis. However, due to its low bioavailability and lack of systematic
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