Evidence map›Paper›PMID 40964661›Full record

ArticleAdvanced functional materials2025

Advances and challenges in human 3D solid tumor models.

Naveen R Natesh, Shyni Varghese

Abstract read
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Naveen R NateshDepartment of Biomedical Engineering, Duke University, 203 Research Drive, MSRB1 Room No. 381, Durham, NC, 27710 USA.
Shyni VargheseDepartment of Biomedical Engineering, Duke University, 203 Research Drive, MSRB1 Room No. 381, Durham, NC, 27710 USA.

Funding

Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcomaR01CA251407 · NCI · DUKE UNIVERSITY · PI ALMAN, BENJAMIN AARON · 2021 to 2025
$2.2M
NCI NIH HHS R01 CA251407
6 · The paper itself

Abstract

The field of cancer biology and therapeutics has soared in the past several decades with new therapeutic modalities and options for patients, such as chemoradiotherapy, immunotherapy, and combination therapy. This dramatic success in expanding patient options is primarily attributed to the development of various model systems to elucidate drivers of oncogenesis, tumor maturation and evolution, and response to therapeutics. While mouse models have been a workhorse of cancer research, technological progress in

Identifiers

PMID40964661
PMCPMC12439845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.