Evidence map›Paper›PMID 40964562›Full record

ArticleCureus2025

Endovascular Management of Traumatic Intracranial Aneurysms Using the Pipeline Flex Embolization Device With Shield Technology Under Single Antiplatelet Therapy: A Case Report and Literature Review.

Jun Isozaki, Hidetaka Onodera, Masao Shioda, Katsumi Sakata, Tetsuya Yamamoto

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun IsozakiDepartment of Neurosurgery, Yokohama City University Medical Center, Yokohama, JPN.
Hidetaka OnoderaDepartment of Neurosurgery, Yokohama City University Medical Center, Yokohama, JPN.
Masao ShiodaDepartment of Neurosurgery, St. Marianna University School of Medicine Hospital, Kawasaki, JPN.
Katsumi SakataDepartment of Neurosurgery, Yokohama City University Medical Center, Yokohama, JPN.
Tetsuya YamamotoDepartment of Neurosurgery, Yokohama City University Medical Center, Yokohama, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic intracranial aneurysms (TICAs) are rare but critical lesions that develop following head injury, carrying a high risk of rupture due to their nature as pseudoaneurysms. Traditional treatments, such as surgical clipping/ligation and coil embolization, have been used to manage TICAs; however, these approaches have significant limitations, including high invasiveness and risk of rebleeding. Flow diverter stents (FDS) have emerged as a promising parent vessel-preserving option, yet managing periprocedural antiplatelet therapy remains a significant challenge, particularly in polytrauma patients. A critical question persists: can FDS be safely and effectively deployed with a minimized antiplatelet burden in patients at high risk of bleeding? This report describes a single case and reviews existing literature on FDS treatment for TICAs, specifically highlighting reports demonstrating the safety and efficacy of single antiplatelet therapy (SAPT) using the Pipeline Flex Embolization Device with Shield Technology (PED-Shield, Medtronic Inc., Irvine, CA, USA). The patient was a woman who sustained a severe head injury from traffic trauma, presenting with bilateral petrous bone fractures, a clivus fracture, and subarachnoid hemorrhage within the basal cisterns and bilateral Sylvian fissures. Initial CT angiography (CTA) on the day of injury showed no aneurysm; however, CTA on post-injury day 8 revealed a new pseudoaneurysm at the petrous-to-cavernous junction of the right internal carotid artery. Given her high bleeding risk due to polytrauma and a brain contusion necessitating decompressive craniectomy on post-injury day 2, PED-Shield was deployed under SAPT, with aspirin as the sole antiplatelet agent. The postoperative course was uneventful. Although the patient experienced attention deficits due to the cerebral contusion, she is living independently with a modified Rankin Scale score of 3. Angiography at 25 days confirmed complete aneurysm occlusion with excellent parent vessel preservation; this favorable outcome persisted at the seven-month follow-up. Our experience suggests that FDS can effectively prevent early rupture and achieve successful occlusion in TICAs. This observation aligns with existing literature demonstrating high complete occlusion rates and the ability to avoid delayed rupture with FDS treatment of TICAs. Furthermore, this case highlights a particularly significant advancement: despite no previous reports of PED-Shield use under SAPT in trauma cases, its antithrombogenic surface coating allowed treatment with SAPT, effectively mitigating the constraints of dual antiplatelet therapy (DAPT) in polytrauma patients. This approach is supported by several reports indicating the safety and efficacy of minimized antiplatelet therapy with PED-Shield in nontraumatic cases. FDS can preserve the parent vessel while ensuring durable aneurysm exclusion. In polytrauma patients, PED-Shield may reduce the limitations imposed by DAPT. This strategy represents a valuable addition to the treatment armamentarium for TICAs.

Indexed as

2-methacryloyloxyethyl phosphorylcholine polymerdual antiplatelet therapyflow diverter stentsminimized antiplateletparent vessel preservationpipeline flex embolization deviceshield technologysingle antiplatelet therapytraumatic intracranial aneurysm

Identifiers

PMID40964562
PMCPMC12439516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.