ArticleStatistics in biosciences2021
Intergenerational Associations Between Maternal Diet and Childhood Adiposity: A Bayesian Regularized Mediation Analysis.
Article in Statistics in biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Growing evidence supports a positive association between childhood obesity and chronic diseases in later life. It is also suggested that childhood obesity is more prevalent for children born from pregnancies complicated by metabolic disorders such as gestational diabetes, and can be related to maternal dietary factors during gestation. Extending conventional analyses that report only the marginal associations within non-causal mediation frameworks, we present mediation analysis in the case of multiple exposures and multiple mediators using a regularized two-stage approach. By placing shrinkage priors on each parameter relating to direct and indirect effects, a parsimonious model can be obtained, and consequently, the most relevant pathways will be selected to inform the development of efficient prevention programs. We apply this method to data from the Danish site of the Diabetes & Women's Health Study, Danish National Birth Cohort (DNBC), and find 6 significant maternal risk factors either directly or indirectly affecting childhood body mass index
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