ArticleCancer management and research2025
SMARCA2 Deficiency While Preserving SMARCA4 in Lung Adenocarcinoma Combined with Abnormal β-Catenin Expression.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The SWI/SNF complex is comprised of ATPase catalytic subunit SMARCA4/SMARCA2, evolutionarily conserved core subunits including SMARCB1, SMARCC1, and SMARCC2, as well as functionally specialized accessory subunits PBRM1 and ARID1A. Deletion or mutation of the catalytic subunit can lead to inactivation of the encoded protein and impaired overall function of the complex, contributing to tumorigenesis. Methods: In this study, we conducted a retrospective analysis of seven cases of poorly differentiated lung adenocarcinoma from our institution that exhibited SMARCA2 deficiency while retaining SMARCA4 expression, and systematically evaluated the clinical characteristics, histological features, genetic alterations, and survival outcomes. Results: Among the seven cases of SMARCA2-deficient lung adenocarcinoma, five were male and two were female, with an average age of 68.7 years. Four patients had a smoking history averaging 35 years, all seven patients exhibited respiratory symptoms. Histologically, these tumors displayed diverse features, including rhabdoid morphology, giant cells, and necrotic areas. The tumor cells exhibited eosinophilic cytoplasm, large nuclei with prominent nucleoli. Immunohistochemically, the tumor cells revealed SMARCA2 negativity with SMARCA4 expression. P53 staining revealed diffuse strong nuclear expression in 5 cases and complete absence expression in 2 cases. β-catenin expression was partially abnormal in 3 cases, with positive nuclear and cytoplasmic staining. PD-L1 expression was detected as positive in 5 cases. Next-generation sequencing identified mutations in driver genes KRAS, MET, and EGFR in 4 cases, and TP53 mutations in 7 cases. Clinical follow-up revealed that 2 patients died of tumor progression, 5 patients achieved complete response within a follow-up period of 10 to 33 months (median = 18.3 m). Conclusion: SMARCA2-deficient with SMARCA4-preserved lung adenocarcinomas demonstrate substantial histological heterogeneity and may dedifferentiate into high-grade adenocarcinomas harboring TP53 mutations. In the assessment of poorly differentiated lung adenocarcinoma, immunohistochemical detection can identify this subtype for more precise clinical treatment strategies.
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