ArticlebioRxiv : the preprint server for biology2025
No Distinct Gut Microbiome Signature in Alzheimer's Disease: A Reanalysis with Modern Tools.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
Funding
Abstract
Alzheimer's Disease (AD) is a neurodegenerative disorder that affects memory, cognition, and behavior. This study reanalyzes a publicly available 16S rRNA sequencing dataset (PRJNA554111) of fecal samples from 43 AD patients and 43 age-and-sex-matched controls to assess differences in microbial composition between the groups. We outlined the relative abundances of major phyla, and identified 137 ASVs across five phyla that were differentially abundant (padj<0.05). We found no distinct pattern of microbial composition distinguishing AD from controls, contrary to the original finding of disease-specific signatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.