Evidence map›Paper›PMID 40964395›Full record

ArticlebioRxiv : the preprint server for biology2025

Cryo-EM structure of a methanogen nitrogenase-PII protein supercomplex.

Rajnandani Kashyap, Thomas M Deere, Ahmed Dhamad, Melissa Chanderban, Monika Tokmina-Lukaszewska, Brian Bothner, Daniel J Lessner, Edwin Antony

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rajnandani KashyapDepartment of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9141-1168
Thomas M DeereDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR, USA.
Ahmed DhamadDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR, USA.
Melissa ChanderbanDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR, USA.
Monika Tokmina-LukaszewskaDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT, USA.ORCID 0000-0003-3298-8298
Brian BothnerDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT, USA.ORCID 0000-0003-1295-9609
Daniel J LessnerDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR, USA.ORCID 0000-0002-5323-8755
Edwin AntonyDepartment of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1888-054X

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for MetabolomicsS10OD028650 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI BOTHNER, BRIAN P · 2020 to 2020
$599k
NIGMS NIH HHS P20 GM103474NIH HHS S10 OD028650
6 · The paper itself

Abstract

Nitrogenases are metalloenzymes that catalyze the reduction of atmospheric dinitrogen to ammonia, sustaining the global nitrogen cycle. While bacterial nitrogenase has been extensively characterized, the architecture and regulation of archaeal nitrogenases remain unknown despite longstanding evidence of nitrogen fixation in methanogens. Here we report a 3.1 Å cryo-electron microscopy structure of a native nitrogenase-PII protein supercomplex from

Identifiers

PMID40964395
PMCPMC12439982

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.