Evidence map›Paper›PMID 40964387›Full record

ArticlebioRxiv : the preprint server for biology2025

Temporal dynamics of CNS cholesterol esters correlate with demyelination and remyelination.

Nishama De Silva Mohotti, Jenna M Williams, Rashmi Binjawadagi, Hiroko Kobayashi, Disni Dedunupitiya, Jack M Petersen, Alana Garcia, Meredith D Hartley

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nishama De Silva MohottiDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.ORCID 0009-0007-4076-686X
Jenna M WilliamsDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Rashmi BinjawadagiDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Hiroko KobayashiDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.ORCID 0000-0002-1551-8844
Disni DedunupitiyaDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Jack M PetersenDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Alana GarciaDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Meredith D HartleyDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.ORCID 0000-0001-6229-2895

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
Women's Alzheimer's Risk Reduction in MidlifeP20GM152280 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HEATHER R DESAIRE · 2024 to 2026
$10.0M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Susan M Lunte · 2022 to 2026
$6.9M
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P20 GM152280NIGMS NIH HHS P30 GM145499NIH HHS S10 OD032207
6 · The paper itself

Abstract

Elevated cholesterol ester levels have been observed in the CNS of patients with neurological diseases, yet the source of cholesterol ester accumulation and whether it is directly linked to demyelination remains undefined. This study investigates the temporal dynamics of cholesterol esters using the

Indexed as

ACAT1astrocytesbraincholesterol esterDemyelinationLCATlipid dropletsmicrogliaremyelinationspinal cordthyroid hormone agonists

Identifiers

PMID40964387
PMCPMC12439923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.