Evidence map›Paper›PMID 40964385›Full record

ArticlebioRxiv : the preprint server for biology2025

EHMT2 Controls Neural Crest-Derived Craniofacial Development but is Dispensable in Limb Development.

Ye Liu, Yaguang Zhao, Minmin Liu, Paul Kim, Ji Liao, Di Lu, Huadie Liu, Piroska E Szabó, Tao Yang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ye LiuDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.ORCID 0000-0002-4845-6643
Yaguang ZhaoDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Minmin LiuDepartment of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Paul KimDepartment of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Ji LiaoDepartment of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Di LuDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Huadie LiuDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
Piroska E SzabóDepartment of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.ORCID 0000-0001-9314-7009
Tao YangDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.

Funding

Role of Desumoylase SENP6 in Joint Aging and Osteoarthritis DevelopmentR01AG061086 · NIA · VAN ANDEL RESEARCH INSTITUTE · PI YANG, TAO · 2019 to 2023
$2.5M
Endogenous retrovirus in joint aging and osteoarthritis developmentR01AG083568 · NIA · VAN ANDEL RESEARCH INSTITUTE · PI Ting Wang, Tao Yang · 2023 to 2026
$2.4M
NIA NIH HHS R01 AG061086NIA NIH HHS R01 AG083568
6 · The paper itself

Abstract

Post-translational modifications of histones, such as methylation of histone H3 at lysine 9 (H3K9), play critical roles in regulating chromatin structure and gene expression. EHMT2 (also called G9A), a histone methyltransferase, mediates H3K9 mono- and dimethylation and has been implicated in both transcriptional repression and context-specific gene activation. Although global knockout of the mouse

Identifiers

PMID40964385
PMCPMC12439983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.