Evidence map›Paper›PMID 40964373›Full record

ArticlebioRxiv : the preprint server for biology2025

Next-generation hybridization chain reaction tools with enhanced sensitivities to detect challenging targets.

Chanpreet Singh, Namrata Bali, Gerard M Coughlin, Jin Xu, Juni Y Polansky, Ulrich Herget, Madelyn S Gilbert, Tasha Cammidge, Giada Spigolon, Yelena Smirnova and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chanpreet SinghTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Namrata BaliTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Gerard M CoughlinTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jin XuTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Juni Y PolanskyTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Ulrich HergetTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Madelyn S GilbertTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Tasha CammidgeTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Giada SpigolonTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Yelena SmirnovaTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Viviana GradinaruTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Kai ZinnTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-6706-5605
David A ProberTianqiao and Chrissy Chen Institute for Neuroscience, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-7371-4675

Funding

MOLECULAR GENETICS OF DROSOPHILA CNS DEVELOPMENTR01NS028182 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Engin Ozkan, KAI G ZINN · 1990 to 2026
$7.3M
Genetic and Neuronal Mechanisms that Regulate Zebrafish Sleep - DIVERSITY SUPPLEMENTR35NS122172 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI David Aaron Prober · 2021 to 2026
$6.1M
Circuit-Specific Delivery of Large Cargo Across the Nervous Systems of Adult Mammals and Embryos via Novel Engineered Systemic VectorsDP1NS111369 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRADINARU, VIVIANA · 2018 to 2023
$5.9M
NINDS NIH HHS DP1 NS111369NINDS NIH HHS R01 NS028182NINDS NIH HHS R35 NS122172
6 · The paper itself

Abstract

Compared to traditional enzyme-based

Indexed as

Deep tissue imagingHCR-CatHCR-ImmunoHCR-MultiHybridization Chain Reaction (HCR)In situ transcript detectionSingle-molecule detectionThick tissue clearing

Identifiers

PMID40964373
PMCPMC12440025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.