Evidence map›Paper›PMID 40964338›Full record

ArticlebioRxiv : the preprint server for biology2025

A hierarchical framework for cortical and subcortical gray-matter parcellation across rodents, primates, and humans.

Siva Venkadesh, Yuhe Tian, Wen-Jieh Linn, Jessica Barrios Martinez, Harrison Mansour, James Cook, David J Schaeffer, Diego Szczupak, Afonso C Silva, G Allan Johnson and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Siva VenkadeshDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8112-0578
Yuhe TianDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Wen-Jieh LinnDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jessica Barrios MartinezDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Harrison MansourDuke Center for In Vivo Microscopy, Departments of Radiology and Biomedical Engineering, Duke University, Durham, NC, USA.
James CookDuke Center for In Vivo Microscopy, Departments of Radiology and Biomedical Engineering, Duke University, Durham, NC, USA.
David J SchaefferDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Diego SzczupakDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Afonso C SilvaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
G Allan JohnsonDuke Center for In Vivo Microscopy, Departments of Radiology and Biomedical Engineering, Duke University, Durham, NC, USA.
Fang-Cheng YehDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Ultra-high Resolution Structural Connectome Atlases of the Animal Brain and their Associated ToolboxR01NS120954 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FANG-CHENG YEH · 2022 to 2026
$2.8M
Global studies into the Genetic Architecture of the Brain's White Matter Network through Harmonized and Coordinated Analyses in the ENIGMA-ConsortiumR01MH134004 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Neda Jahanshad · 2023 to 2026
$2.6M
NIMH NIH HHS R01 MH134004NINDS NIH HHS R01 NS120954
6 · The paper itself

Abstract

Translational neuroscience requires consistent anatomical frameworks to compare brain organization across species despite differences in size and specialization. Existing atlases are species-specific, limiting cross-species analyses. Here we constructed population-averaged minimal deformation templates for rodents, nonhuman primates, and humans, and developed a hierarchical common atlas delineating homologous cortical and subcortical gray matter regions through landmark-guided boundaries and multimodal nonlinear registration. Validation against species-specific atlases confirmed strong regional correspondence and revealed systematic volumetric scaling, with humans showing expanded associative cortices and rodents emphasizing limbic and sensorimotor areas. This freely available atlas provides a unified coordinate system supporting comparative imaging, developmental analyses, and cross-species connectomics, facilitating investigations into conserved and divergent brain organization across species.

Indexed as

comparative neurosciencecortical gray mattercross-species atlasminimal deformation templates

Identifiers

PMID40964338
PMCPMC12439950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.