Evidence map›Paper›PMID 40964320›Full record

ArticlebioRxiv : the preprint server for biology2025

General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants.

Austin Tedman, John A Olson, Minsoo Kim, Catherine Foye, JaNise J Jackson, Eli F McDonald, Andrew G McKee, Karen Noguera, Charles P Kuntz, Jens Meiler and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Austin TedmanThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
John A OlsonDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Minsoo KimDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Catherine FoyeDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
JaNise J JacksonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Eli F McDonaldDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Andrew G McKeeDepartment of Chemistry, Indiana University, Bloomington, IN, USA.
Karen NogueraDepartment of Chemistry, Indiana University, Bloomington, IN, USA.
Charles P KuntzThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Jens MeilerDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-8945-193X
Kathryn OliverDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7781-7006
Lars PlateDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Jonathan P SchlebachThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-0955-7633

Funding

Coordination of chaperone interactions that dictate protein folding and traffickingR35GM133552 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2019 to 2026
$3.2M
Rational optimization of combinatorial therapies for the treatment of rare cystic fibrosis variantsR01HL167046 · NHLBI · PURDUE UNIVERSITY · PI Lars Plate, Jonathan Patrick Schlebach · 2023 to 2026
$2.7M
Molecular Chaperone Recognition of CFTR StabilityF31HL162483 · NHLBI · VANDERBILT UNIVERSITY · PI MCDONALD, ELI FRITZ · 2022 to 2023
$58k
NHLBI NIH HHS F31 HL162483NHLBI NIH HHS R01 HL167046NIGMS NIH HHS R35 GM133552
6 · The paper itself

Abstract

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (

Identifiers

PMID40964320
PMCPMC12439906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.