Evidence map›Paper›PMID 40964316›Full record

ArticlebioRxiv : the preprint server for biology2025

The role of intrinsically disordered domains in regulating G protein coupled receptor signaling.

Jun Xu, Ruoyi Qiu, Alexander M Garces, Harald Hübner, Xinyu Xu, Dorothee Weikert, Peter Gmeiner, Michael T Lerch, Brian K Kobilka

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jun XuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.
Ruoyi QiuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.
Alexander M GarcesDepartment of Biophysics, Medical College of Wisconsin; Milwaukee, WI, USA.
Harald HübnerDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universita t Erlangen-Nu rnberg; Erlangen, Germany.
Xinyu XuDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Dorothee WeikertDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universita t Erlangen-Nu rnberg; Erlangen, Germany.
Peter GmeinerDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universita t Erlangen-Nu rnberg; Erlangen, Germany.
Michael T LerchDepartment of Biophysics, Medical College of Wisconsin; Milwaukee, WI, USA.
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.

Funding

G protein coupled receptor structure, dynamics, and signaling.R35NS137408 · NINDS · STANFORD UNIVERSITY · PI Brian K Kobilka · 2024 to 2026
$1.9M
Regulation of β2-adrenergic receptor signaling by post-translational modificationsR01GM135581 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI LERCH, MICHAEL TAYLOR · 2019 to 2023
$1.7M
Upgrades to a Bruker Q-band E580 Pulse EPR SpectrometerS10OD025260 · OD · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2019 to 2019
$478k
NIGMS NIH HHS R01 GM135581NIH HHS S10 OD025260NINDS NIH HHS R35 NS137408
6 · The paper itself

Abstract

The α

Identifiers

PMID40964316
PMCPMC12439954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.