Evidence map›Paper›PMID 40964311›Full record

ArticlebioRxiv : the preprint server for biology2025

CA2 neurons show abnormal responses to social stimuli in a rat model of Fragile X syndrome.

Margaret M Donahue, Emma Robson, Alyssa M Marron, Edel J Fernandez, Misty Hill, Alexandra J Mably, John B Trimper, Darrin H Brager, Laura Lee Colgin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaret M DonahueInterdisciplinary Neuroscience Program, The University of Texas at Austin, Austin, Texas, 78712.ORCID 0000-0002-9356-3720
Emma RobsonCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas, 78712.
Alyssa M MarronInterdisciplinary Neuroscience Program, The University of Texas at Austin, Austin, Texas, 78712.
Edel J FernandezCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas, 78712.
Misty HillCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas, 78712.
Alexandra J MablyCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas, 78712.
John B TrimperCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas, 78712.
Darrin H BragerCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas, 78712.
Laura Lee ColginInterdisciplinary Neuroscience Program, The University of Texas at Austin, Austin, Texas, 78712.ORCID 0000-0002-4853-8913

Funding

Investigating mechanisms underlying impaired social and spatial cognition in rodent models of Fragile X syndromeR01MH131317 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H, COLGIN, LAURA L · 2022 to 2025
$3.0M
Physiological mechanisms underlying disrupted hippocampal function in Fragile X syndromeR56MH125655 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H, COLGIN, LAURA L · 2021 to 2022
$1.2M
Mechanisms underlying impaired hippocampal physiology in Fragile X SyndromeF31MH127933 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI DONAHUE, MARGARET MCNEIL · 2022 to 2023
$88k
NIMH NIH HHS F31 MH127933NIMH NIH HHS R01 MH131317NIMH NIH HHS R56 MH125655
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is a neurodevelopmental disorder that is highly comorbid with autism spectrum disorders and can cause abnormal social behaviors. The CA2 subregion of the hippocampus is essential for social memory processing and social recognition. A social interaction induces changes in CA2 neuronal firing; however, it is unknown whether these changes are impaired in FXS models. Here, we examined CA2 activity in a rat model of Fragile X Syndrome (

Identifiers

PMID40964311
PMCPMC12439897

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.